In order to explore novel anti-inflammatory agents, some novel mefenamic acid derivatives as potential non-steroidal antiinflammatory agents (NSAIDs) were synthesized and characterized by IR, H-NMR, C-NMR, mass and elemental analysis. The anti-inflammatory activities of the target compounds were evaluated via the croton oil-induced ear oedema test in mice. According to screened results, compoun...

background: primary dysmenorrhea refers to the occurrence of painful menstrual cramps of uterus and is considered as a gynecological complaint. the common treatment for this problem is medical therapy such as mefenamic acid [non‑steroidal anti‑inflammatory drugs (nsaids)] and oral contraceptive pills, both of which work by reducing myometrial activity. fennel contains an antispasmodic and aneth...

The content of flavonoid compounds in betel leaf is used as a protection analgesic. purpose this study was to test the analgesic effects Banyuwangi green extract (Piper betle L.) on male white mice (Mus musculus). doses ethanol that were 4.696 mg, 9.392 mg and 18.784 positive control mefenamic acid. animals musculus) adapted for about 3 days experimental environmental conditions. Based results ...

Previously a standard toxicological test termed as DarT (Danio rerio Teratogenic assay) using wild type zebrafish embryos has been established and it is widely applied in toxicological and chemical screenings. As an increasing number of fluorescent transgenic zebrafish lines with specific fluorescent protein expression specifically expressed in different organs and tissues, we envision that the...

The objective of the present work is to prepare Mefenamic acid loaded bovine serum albumin nanoparticles by Desolvation technique. Drug-polymer dispersion was prepared under continuous mechanical stirring. Desolvating agent was added by means of two methods. In continuous addition method desolvating agent was added at the rate of 1ml/1min whereas in Intermittent addition method the desolvating ...

Objective(s): The aim of present study is to formulate mefenamic acid transdermal gel based on vesicular drug delivery approaches.Materials and Methods: For the preparation of mefenamic acid transdermal gel, transfersomes were selected as colloidal carriers. Transfersomes were prepared by hand shaking and thin film hydration techniques. The obtained transfersomes were characterized for vesicula...