To investigate the functional relationship between the transforming ability of Ras and its role as an integral component of the differentiation-promoting insulin signaling pathway, we introduced a Ieu6l-activated ras gene into the Ras-transformable 3T3 LI (ATCC CCL92.1) and a number of C3HIOT1/ -derived preadipocytic cell lines. The results demonstrate a quantitative reciprocal regulation of di...

One of the main concerns of scholars working in the field of EAP over the last 2decades has been raising the awareness of EAP students and publishers of genreconventions in academic journals. In line with the above concern, many studies haveaimed at exploring the general characteristics of research articles (RAs) in the field.Among these features, it seems that the generic moves and textuality ...

R-Ras has a high degree of sequence homology to Ras and to other members of the Ras subfamily including Rap, TC21 and M-Ras. Activated versions of Ras and TC21 are highly transforming in a variety of cell lines and mutated forms of both proteins have been found in human tumours. R-Ras interacts with many of the same proteins as Ras and TC21, including c-Raf1, and can induce transformed foci, al...

Ras GTPases undergo post-translational modifications that govern their subcellular trafficking and localization. In particular, palmitoylation of the Golgi tags N-Ras and H-Ras for exocytotic transport and residency at the PM (plasma membrane). Following depalmitoylation, PM-Ras redistributes to all subcellular membranes causing an accumulation of palmitate-free Ras at endomembranes, including ...

Ras proteins transduce signals from membrane-bound receptors via multiple downstream effector pathways and thereby affect fundamental cellular processes, including proliferation, apoptosis, and differentiation. K-ras activating mutations play a key role in neoplastic progression and are particularly prevalent in colorectal, pancreatic, and lung cancers. The present study addressed whether the K...

PURPOSE Activation of the RAS pathway plays a major role in cancer cells. In acute myeloid leukemia (AML), mutations of the RAS genes cause an intrinsic activation of this pathway. Until now, clinical studies could not find clear association of RAS mutations with the clinical outcome after AML therapy. This could be due to alternative initiating events for activation of the RAS pathway like con...

This multicentric, multinational, randomised controlled trial (RCT) was aimed to see if percutaneous revascularisation of the renal arteries in atherosclerotic renovascular disease provided clinical benefits. A total of 806 patients in whom the benefits of revascularisation were thought to be uncertain by their treating physicians were randomised to the medical therapy or the revascularisation ...