BACKGROUND Long-QT syndrome type 2 (LQT2) is caused by mutations in the human ether-a-go-go-related gene (hERG). More than 30% of the LQT2 mutations result in premature termination codons. Degradation of premature termination codon-containing mRNA transcripts by nonsense-mediated mRNA decay is increasingly recognized as a mechanism for reducing mRNA levels in a variety of human diseases. Howeve...

Abstract RNA-based therapies have great potential to treat many undruggable human diseases. However, their efficacy, in particular for mRNA, remains hampered by poor cellular delivery and limited endosomal escape. Development optimisation of vectors, such as lipid nanoparticles (LNPs), are impeded screening methods probe the intracellular processing LNPs sufficient detail. We developed a high-t...

Background: It has been proposed that oxidative stress may contribute to the development of testicular abnormalities in diabetes. Morus alba leaf extract (MAE) has hypoglycemic and antioxidant properties. We, therefore, explored the impact of the administration of MAE on steroidogenesis in diabetic rats. Methods: To address this hypothesis, we measured the serum level of glucose, insulin, and f...

Introduction: N-acetyltransferase 10 (NAT10) is the only confirmed regulator to mediate N4-acetylcytidine (ac4C) modification of mRNA and crucial for stability translation efficiency. However, its role in diffuse large B-cell lymphoma (DLBCL) development prognosis has not yet been explored. Herein, we explored functional significance regulatory mechanism NAT10 mediated ac4C DLBCL, which expecte...

fcεri, the high affinity receptor for ige plays a critical role in triggering the allergic reactions. it is responsible for inducing mast cell degranulation and deliberation of allergy mediators when it is aggregated by allergen and ige complexes. fcεri on the mast cells consists of three subunits; α chain directly binds ige, β chain and dimmer of γ chains together mediate intracellular signali...