BACKGROUND Primary mediastinal malignant germ cell tumors (GCTs) are rare and have a worse prognosis than their gonadal counterparts. Although multimodality treatment is a standard therapeutic strategy in mediastinal GCTs, the clinical implications of surgical intervention remain unclear. METHODS Forty-eight patients with primary mediastinal malignant GCT who were treated at the National Canc...

Paragangliomas are unusual neuroendocrine cell tumors arising from paraganglia, of which ACTH-secreting cases in the mediastinum are extremely rare. A 51-year-old woman was admitted for generalized edema and weakness which began 5 months ago. Chest X-ray and CT scan revealed a tumor mass in the anterior mediastinum. The plasma cortisol and ACTH levels were very high. Other sources secreting ACT...

superior vena cava syndrome is a common presentation of bronchogenic carcinoma. the mechanism of obstruction is by compression of superior vena cava by the bronchogenic tumor itself or enlarged mediastinal lymph nodes. however obstruction due to intravascular thrombosis is extremely uncommon. here, we report a rare case of a 65-year-old male smoker who presented with superior vena cava syndrome...

Background: Synovial sarcoma mediastinum is a rare tumor, with few cases having been reported.Case Presentation: A 27-year-old Indonesian woman had complaint of shortness breath and left chestpain. Chest X-ray showed massive pleural effusion reddish-yellow fluid. Thorax CT scanshowed clear demarcated mass in the anterior until medius, value lactic aciddehydrogenase 561 U/L. The patient was diag...

A 35-year-old Japanese man's routine chest radiography revealed an abnormal opacity. Chest computed tomography and magnetic resonance imaging showed a 5.5 cm in dia. cystic tumor located at the left anterior mediastinum. The tumor was suspected to be an asymptomatic thymic cyst, and we chose observation for the tumor. At the 3-year follow up, the cystic tumor had gradually enlarged to 7.5 cm in...

Myelolipoma (ML) is an uncommon benign mesenchymal neoplasia composed of mature adipose and hematopoietic tissues of uncertain etiology. Less than 3% of MLs occur in the mediastinal topography. The main differential diagnosis involves extramedullary hematopoiesis; therefore, pathological evaluation is essential for the definitive diagnosis. The authors report the case of a 50-year-old man diagn...

INTRODUCTION The abscopal effect is the effect of radiation therapy at a site distant to the area of irradiation. This is not a common event and has not been clearly defined, resulting in few reported cases in the literature. We discuss this phenomenon in a patient with hepatocellular carcinoma. CASE PRESENTATION A 63-year-old Japanese man underwent extended right hepatic lobectomy for hepato...

PURPOSE To evaluate the outcomes and prognostic factors in children with extracranial germ cell tumors (GCTs) treated at a single institution. METHODS Sixty-six children diagnosed with extracranial GCTs between 1996 and 2012 were included in the study. Primary treatment was surgical excision, followed by six cycles of cisplatin-based chemotherapy. The survival rates were compared according to...