We describe injuries to the posterior root of the medial meniscus in patients with spontaneous osteonecrosis of the medial compartment of the knee. We identified 30 consecutive patients with spontaneous osteonecrosis of the medial femoral condyle. The radiographs and MR imaging were reviewed. We found tears of the posterior root of the medial meniscus in 24 patients (80%). Of these, 15 were com...

Abstract Background Medial open-wedge high tibial osteotomy (HTO) is an effective and safe treatment method for medial osteoarthritis of the knee. However, unintended changes in posterior slope (PTS) may occur. Several factors cause PTS alterations after HTO; however, research on sagittal-plane inclination (SPOI) relation to sparse. The purpose this study was evaluate whether SPOI affects HTO. ...

OBJECTIVE Osteoarthritis is a global clinical challenge for which no effective disease-modifying agents currently exist. This study identified protease-activated receptor 2 (PAR-2) as a novel pathogenic mechanism and potential therapeutic target in osteoarthritis. METHODS Experimental osteoarthritis was induced in wild-type and PAR-2-deficient mice by sectioning the medial meniscotibial ligam...

OBJECTIVES To investigate differing patterns and associations of osteoarthritis of the knee in patients referred to hospital. METHODS Two hundred and fifty two consecutive patients (161 women, 91 men; mean age 70 years, range 34-91 years) referred to hospital with osteoarthritis of the knee underwent clinical, radiographic, and synovial fluid screening. RESULTS Radiographic changes of osteo...

OBJECTIVES It has been suggested that the lysosomal recycling process called macro-autophagy plays a role in osteoarthritis development. We thus decided to genetically ablate the autophagy-indispensable Atg5 gene specifically in chondrocytes and analyse the development of osteoarthritis upon aging and in a post-traumatic model. METHODS Mice lacking the Atg5 gene in their chondrocytes (Atg5cKO...

The aim of this study was to determine the correlation between level deformation, degeneration rate knee joint, and change in structure subchondral bone layer affected by osteoarthritis women. included patients diagnosed with primary osteoarthritis, varus planned for surgical treatment form arthroplasty. underwent a clinical radiological assessment using standard radiographs joints anterior–pos...

BACKGROUND Osteoarthritis (OA) of the knee is characterized by pain and activity limitations. In knee OA, proprioceptive accuracy is reduced and might be associated with pain and activity limitations. Although causes of reduced proprioceptive accuracy are divergent, medial meniscal abnormalities, which are highly prevalent in knee OA, have been suggested to play an important role. No study has ...