Sepsis is a frequent cause of death in very-low-birthweight infants and often results in neurological impairment. Its attributable risk of sequelae has not been systematically assessed. To establish an outcome tree for mapping the burden of neonatal sepsis, we performed systematic literature searches to identify systematic reviews addressing sequelae of neonatal sepsis. We included cohort studi...

Background & Objective: Neonatal sepsis is one of the leading causes of mortality in neonatology wards. The aim of this study was to assess sepsis pathogens and antibacterial resistance patterns in a teaching hospital during seven years in Tehran, Iran. Methods: In this retrospective study, all neonates suspected to seps...

Neonatal sepsis is one of the important causes of mortality in the newborn. If treated early with the appropriate antibiotics it is possible to prevent most of the neonatal deaths due to sepsis. This study was conducted in the neonatal intensive care unit, Nepal Medical College Teaching Hospital, Kathmandu, Nepal over a period of 2 years from April 2012 to March 2014.This was a prospective stud...

Objective: To study the maternal risk factors and clinico-bacteriological profile of early onset sepsis (EOS) and performance of sepsis screen parameter in a tertiary care neonatal unit. Methods: Relevant data of neonates born during the study period were obtained from their case records. A diagnosis of early onset sepsis was made if either clinical sepsis developed within 48 hours of life and ...

The co-inhibitory immune receptor carcinoembryonic antigen-related cell-adhesion molecule 1 (CEACAM1) and its self-ligand CEACAM1 can suppress T cell function. Suppression of T cell function in sepsis is well documented. Late-onset neonatal sepsis in VLBW-infants was associated with an increased percentage CEACAM1 positive CD4(+) T-cells. Meningococcal septic shock in children was associated wi...

Objective : The aim of the study was to find the correlation of clinical profile and risk factors of neonatal sepsis with culture proven cases. Materials and Method: The study was conducted on 50 neonates a time based prospective study. All consecutive neonates fulfilling the inclusion and exclusion criteria are subjected to sepsis screening. Results: Among risk factors PROM and fetal distress ...

background: the appropriateness of using serum levels of procalcotonin (pct) for early diagnosis of newborn sepsis is still controversial. therefore, the objective of the present study was to compare the usefulness of pct with those of serum levels of c-reactive protein (crp) and white blood cell (wbc) counts in the diagnosis and response to treatment of neonatal sepsis.   methods: a total of 4...

Neonatal mortality is increasingly recognized as an important global public health challenge that must be addressed if we are to reduce child health disparities between rich and poor countries. Most of the estimated 4 million neonatal deaths per year occur in low and middle income countries. Three conditions: infection, birth asphyxia, and consequences of premature birth/low birth weight, are r...

OBJECTIVE The purpose of this study was to compare maternal characteristics and neonatal morbidity and mortality rates that are associated with early-onset neonatal sepsis that is caused by group B Streptococcus and Escherichia coli. STUDY DESIGN This was a retrospective review of newborn infants with a positive blood culture (and/or cerebrospinal fluid) that was positive for either E coli or...

Sepsis is a major cause of neonatal mortality and morbidity worldwide. A recent report suggested that murine neonatal host defense against infection could be compromised by immunosuppressive CD71(+) erythroid splenocytes. We examined the impact of CD71(+) erythroid splenocytes on murine neonatal mortality to endotoxin challenge or polymicrobial sepsis and characterized circulating CD71(+) eryth...