A macromomycin (MCR)-resistant subline of mouse lymphoblastoma L5178Y cells was isolated after successive treatment of tumor-bearing mice with the antibiotic for 7 transplant generations, followed by cloning in culture in MCR-containing soft agar medium. The resistant cell line was about 17 times more resistant to MCR than was the parental cell line and exhibited cross-resistance to neocarzinos...

This study evaluated the potential beneficial effect of Moutan Cortex Radicis (MCR) in a murine model of carbon tetrachloride (CCl(4))-, D-galactosamine (GalN)- and α-naphthylisothiocyanate (ANIT)-induced liver injury. Acute hepatotoxicity was induced by intraperitoneal injection of CCl(4) (10 µL/kg), GalN (700 mg/kg), and ANIT (40 mg/kg). Animals received MCR (30, 100, and 300 mg/kg ) orally a...

This study was designed to investigate the molecular epidemiology of mobile colistin resistance ( mcr ) using a “One-Health” approach in Laos and predict whether any dominant plasmid backbone and/or strain type influences dissemination . We collected 673 samples from humans (rectal normal flora), poultry, environment (water, flies, birds, etc.) Vientiane, Lao People’s Democratic Republic (Laos)...

The minor crossing number of a graph G, mcr(G), is defined as the minimum crossing number of all graphs that contain G as a minor. We present some basic properties of this new minor-monotone graph invariant. We give estimates on mcr for some important graph families using the topological structure of graphs satisfying mcr(G) ≤ k.

This paper describes the upgrading process of the Multilingual Central Repository (MCR). The new MCR uses WordNet 3.0 as Interlingual-Index (ILI). Now, the current version of the MCR integrates in the same EuroWordNet framework wordnets from five different languages: English, Spanish, Catalan, Basque and Galician. In order to provide ontological coherence to all the integrated wordnets, the MCR...

During exercise, increased energy demands are met by increased glucose production that occurs simultaneously with the increased glucose uptake. We had previously observed that, during exercise, metabolic clearance rate of glucose (MCR) increases markedly in normal, but only marginally in poorly controlled diabetic dogs. We wished to determine (i) whether in a more general model of stress matche...

Melt runoff (MR) contributes significantly to the total runoff in many river basins. Knowledge of the meltwater contribution (MCR, defined as the ratio of MR to the total runoff) to the total runoff benefits water resource management and flood control. A process-based land surface model, Noah-MP, was used to investigate the spatiotemporal characteristics of MR and MCR in the Upper Changjiang Ri...

from cats, belonged to ST93 and a new ST strain, respectively. Isolates EC08 and EC09, from the patients who shared the same hospital room with the pet shop worker, were ST156 (Table). Results of pulsed-field gel electro-phoresis were consistent with multilocus sequence typing results and showed that isolates consisted of 5 typeslate EC07 was clonally related to 4 E. coli strains from dogs, acc...