Ferritin is a major iron storage protein and essential for iron homeostasis. It has a wide range of functions in the body including iron delivery, immunosuppression, angiogenesis, and cell proliferation. Ferritin is overexpressed in many cancer cells, but its precise role in cancer is unclear. In the present study, we examined the functional roles of ferritin in protecting the MCF-7 breast canc...

Natural products are the best source for various medicinal drugs. Regardless investigate the toxic effect of these plant extracts, the results will still unsafe and unacceptable. This study aimed to identify anti-cancer activity and cytotoxicity effect of Momordica charantia extract on different cancer cell line. Materials and Methods:to archive the aim of this study 3 different cancer cell lin...

Introduction: Non-target radiation effects are damages and effects that occur without the need for direct radiation exposure in cells. Bystander signals cause non-targeted irradiation effect that has been defined as radiation responses in which non-irradiated cells exhibit irradiated effects as a result of signals from adjacent irradiated cells. In this study, the bystander ef...

Multidrug resistance is a phenomenon that cancer cells develop a cross-resistant phenotype against several unrelated drugs, and permeability glycoprotein derived from the overexpression of multidrug resistance gene 1 has been taken as the most significant cause of multidrug resistance. In the present study, ginsenoside Rh2 was used to reverse permeability glycoprotein-mediated multidrug resista...

Many previous investigations have found quercetin to be a powerful antioxidant and antitumor flavonoid, but its poor bioavailability has limited use. This current study investigated the effects of two newly synthesized Quercetin Schiff bases containing 2-amino thiadiazole-5-thiol (Q1), benzyl derivatives (Q2) on MCF-7 human breast cancer cells. Cell viability apoptosis were assessed determine t...