Many enzymes contain metalloporphyrins as prosthetic groups, which catalyse a vide variety of biologically important reactions. Hence, these species have been studied by a large number of spectroscopic techniques including Magnetic Circular Dichroism Spectroscopy (MCD). This method is especially useful to investigate the electronic structures and spectra of paramagnetic complexes [1]. However, ...

Minimal change disease (MCD) accounts for greater than 90% of cases of nephrotic syndrome in children. In adults, MCD accounts for 10–15% of nephrotic syndrome. FSGS is increasing in incidence in adults and children, and in the USA, in adults, is now the most common cause of nephrotic syndrome w1,2x. MCD shows normal glomeruli by light microscopy. Associated acute interstitial nephritis suggest...

PURPOSE Macular corneal dystrophy (MCD) is an autosomal recessive disorder leading to severe visual impairment. The carbohydrate sulfotransferase 6 (CHST6) gene, which encodes the corneal N-acetylglucosamine 6-O-sulfotransferase on 16q22 has been identified as a causative gene for MCD. The purpose of this study was to identify mutations in CHST6 in Japanese patients with MCD and evaluate them b...

Retinol and its derivative, retinoic acid, have pleiotropic functions including vision, immunity, hematopoiesis, reproduction, cell differentiation/growth, and development. Non-alcoholic fatty liver disease (NAFLD) is one of the most common diseases in developed countries and encompasses a broad spectrum of forms, ranging from steatosis to steatohepatitis, which develops further to cirrhosis. R...

High-valent iron(IV)-oxo species are key intermediates in the catalytic cycles of a range of O2-activating iron enzymes. This work presents a detailed study of the electronic structures of mononuclear ([FeIV(O)(L)(NCMe)]2+, 1, L = tris(3,5-dimethyl-4-methoxylpyridyl-2-methyl)amine) and dinuclear ([(L)FeIV(O)(μ-O)FeIV(OH)(L)]3+, 2) iron(IV) complexes using absorption (ABS), magnetic circular dic...

Multicentric Castleman disease (MCD) is a distinct type of lymphoproliferative disorder associated with inflammatory symptoms and interleukin 6 (IL-6) dysregulation. In the context of human immunodeficiency virus (HIV) infection, MCD is associated with Kaposi sarcoma–associated herpesvirus, also called human herpesvirus type 8 (KSHV/HHV8). Within a prospective cohort study on 60 HIVinfected pat...

BACKGROUND Steroid-sensitive idiopathic nephrotic syndrome (SSINS) is most often encountered in sporadic cases of minimal change disease (MCD). Only rare cases of familial forms of MCD have been reported and most of them only in one generation. The scarcity of data has precluded unraveling the underlying genetic defect and candidate gene approaches have been unsuccessful. Here we report two fam...

Magnetic circular dichroism ~MCD! has been measured for ferromagnetic CoS2 in the S 2p , Co 2p and 3p core absorption regions. MCD in the S 2p region is discussed in terms of the exchange splitting of the unoccupied band. The Co 2p MCD has revealed that the orbital angular momentum of the Co 3d state remains finite in spite of its low-spin configuration. This situation is confirmed by a simple ...

A series of heteroaryl-substituted bis-trifluoromethyl carbinols were prepared and evaluated as malonyl-CoA decarboxylase (MCD) inhibitors. Some thiazole-based derivatives showed potent in vitro MCD inhibitory activities and significantly increased glucose oxidation rates in isolated working rat hearts.