There is an urgent need for an evidence base to guide care for patients with multiple chronic medical conditions (MCC). Comparative effectiveness research (CER) has been touted as 1 solution to generating such evidence. However, the majority of CER topics and methods are designed to generate evidence applicable to single diseases. Generating evidence to guide the care of MCC populations require...

A fifth of worldwide cancer cases have an infectious origin, with viral infection being the foremost. One such cancer is Merkel cell carcinoma (MCC), a rare but aggressive skin malignancy. In 2008, Merkel cell polyomavirus (MCPyV) was discovered as the causative agent of MCC. It is found clonally integrated into the majority of MCC tumours, which require MCPyV oncoproteins to survive. Since its...

Together with an explosive growth of the mobile applications and emerging of cloud computing concept, mobile cloud computing (MCC) has been introduced to be a potential technology for mobile services. MCC integrates the cloud computing into the mobile environment and overcomes obstacles related to the performance (e.g., battery life, storage, and bandwidth), environment (e.g., heterogeneity, sc...

The distribution and density of mast cells in the normal and diseased synovial membranes were investigated. The mast cell count (MCC) in the osteoarthritic (OA) synovium (36.9 +/- 26.9 cells/mm2) was significantly higher than that in the rheumatoid arthritic (RA) synovium (18 +/- 12.3 cells/mm2). There was a marked positive correlation between the MCC and the volume of joint fluid in OA (r = 0....

Merkel cell carcinoma (MCC) is an uncommon highly aggressive skin malignancy with an increased tendency to recur locally, invade regional lymph nodes, and metastasize distally to lung, liver, brain, bone, and skin. The sun-exposed skin of head and neck is the most frequent site of involvement (55%). We report the case of a 63-year-old Caucasian male patient who presented with a recurrent left i...

Mobile Cloud Computing (MCC) integrates mobile computing and cloud computing aiming to extend mobile devices capabilities through offloading techniques. In MCC, many controlled experiments have been performed using mobile applications as benchmarks. Usually, these applications are used to validate proposed algorithms, architectures or frameworks. The task of choosing a specific benchmark to eva...

objective(s): this study evaluates the effect of substitution of microcrystalline cellulose (mcc) with ethylcellulose (ec) on mechanical and release characteristics of theophylline pellets. materials and methods: the effect of addition of ec was investigated on characteristics of pellets with varying drug content prepared by extrusion-spheronization. also the effect of type of granulating liqui...

Abstract Microcrystalline cellulose (MCC) is pure isolated from alpha cellulose. The demand for renewable and sustainable raw materials the industry has developed as one of most pressing challenges in recent decades. seaweed processing produces a large amount solid fibrous waste, which can be utilized an additional source feedstock. increase production continues to increase, well waste that use...

Background: Microcrystalline cellulose (MCC) is a popular dry binder in tablet formulation. Differences its processing methods can significantly affect tableting properties. Aim: Assessment of the and in-vitro release properties diazepam tablets formulated with Gossypiumherbaceum (GH) derived MCC that was dried by two different methods. Methods: G.herbaceum bolls were de-lignified sodium hydrox...

Merkel cell carcinoma (MCC) is a rare but aggressive neuroendocrine skin neoplasia. The merkel cell polyomavirus (MCPyV), a double-stranded DNA tumor virus was discovered in 2008. It is found in approximately 80% of human MCC and is suspected to play a role in MCC development [1]. Both, small tumor and the aminoterminal moiety of the large tumor antigen, were found to be expressed in MCPyV-posi...