The wiggler beamline BW6 at DORIS is dedicated to protein crystallography. The facility is financed by the Max-Planck Society (MPG). It may be used also by other academic or industrial groups on the basis of research proposals or for proprietary research. The webpage www.mpasmb-hamburg.mpg.de/bw6/ provides further information on the access to the beamline. For academic usage, an interactive onl...

PURPOSE To map and identify the genetic defect underlying autosomal dominant cataract segregating in a 5-generation Caucasian American family. METHODS Genomic DNA was prepared from blood leukocytes, genotyping was performed using microsatellite markers, and logarithm of the odds (LOD) scores were calculated using the LINKAGE programs. Mutation profiling was performed using direct exon cycle-s...

background: acid phosphatase (acp) is suggested to be one of the virulence factors in leishmania and a correlation has been reported between leishmanial acid phosphatase (acp) activity and the severity of the disease in all types of leishmaniasis including zoonotic cutaneous leishmaniasis (zcl), which is a polymorphic disease.   objective : characterization of leishmania and its correlation wit...

The versatile optical and biological properties of a localized surface plasmon resonance (LSPR) sensor that responds to protein conformational changes are illustrated. The sensor detects conformational changes in a surface-bound construct of the calcium-sensitive protein calmodulin. Increases in calcium concentration induce a 0.96 nm red shift in the spectral position of the LSPR extinction max...

The impact of three levels of sea salt (0.0, 8.0, and 16.0 mS/cm2) on six varieties of soybean (Crawford, G21, G22, G35, G82, and G83) was studied. Growth criteria, photosynthetic pigments, soluble sugars, soluble protein, free amino acids, free proline, and protein profile of soybean varieties were investigated under sea salt stress. Results of this study showed a considerable decrease in grow...

Membrane surface electrostatic interactions impose structural constraints on imported proteins. An unprecedented sensitive dependence on these constraints was seen in the voltage-gated import and channel formation by the C-terminal pore-forming domain of the bacteriocin, colicin E1. At physiological ionic strengths, significant channel current was observed only in a narrow interval of anionic l...

In present study a proline rich protein has been identified in lentil EST database using (soyabean) glycine max proline rich protein sequence as query sequence known to be down regulated in response to salinity and drought stress. Sequence similarity search has shown 90 % similarity with chickpea EST sequence Accesion no. GR 398344 and 85% similarity with Lens culinaris EST sequence Accession n...