Background The impact of concomitant vitamin D deficiency and maternal hypocalcemia on fetal growth has is not clear. The aim of this study was to determine the effect of treatment with vitamin D on maternal and neonatal indices in pregnant women with hypocalcemia. Materials and Methods This clinical trial was conducted on 110 pregnant women (22-26 weeks of gestational age) with simultaneous m...

objective: to compare the maternal and umbilical cord serum selenium concentrations in low and normal birth weight neonates. materials and methods: a case-control study was carried out in vali-asr and akbarabadi hospitals (jan. to dec. 2013). two groups; case group; 91 mothers who delivered a low birth weight (lbw) neonate and control group; 86 subjects who delivered a normal birth weight neona...

OBJECTIVE To establish a normal range of maternal serum levels of total vitamin D at 11-13 weeks' gestation and examine factors from maternal characteristics and obstetric history affecting these levels. METHODS Serum 25-hydroxyvitamin D [25(OH)D] was measured by liquid chromatography-tandem mass spectrometry in 1,000 singleton pregnancies with normal outcome. Multiple regression analysis was...

BACKGROUND The potential use of plasma and serum for molecular diagnosis has generated interest. Tumour DNA has been found in 'the plasma and serum of cancer patients, and molecular analysis has been done on this material. We investigated the equivalent condition in pregnancy-that is, whether fetal DNA is present in maternal plasma and serum. METHODS We used a rapid-boiling method to extract ...

Environmental exposures in-utero may alter the epigenome, thus impacting chromosomal stability and gene expression. We hypothesized that in utero exposures to maternal smoking and perfluoroalkyl compounds (PFCs) are associated with global DNA hypomethylation in umbilical cord serum. Our objective was to determine if global DNA methylation could be used as a biomarker of in utero exposures to ma...

Maternal serum uric acid was determined in 30 preeclamptic and 20 normal pregnant females in their third trimester. Serum uric acid was 3.52± 0.75 in normal pregnancies and 6.03 ± 1.67 in preeclamptic pregnancies. This increase in serum uric acid was highly significant (P<0.001). There was no influence of parity and maternal age on serum uric acid. Serum uric acid levels increased significantly...

BACKGROUND Evidence exists that maternal zinc status during pregnancy is linked to adverse pregnancy outcomes including abortion, fetal growth restriction, and neural tube defects. However, it remains unclear whether maternal serum zinc concentration (SZC) during pregnancy is associated with risk of preterm birth. OBJECTIVE This study was designed to investigate the association between matern...

Polybrominated diphenyl ethers (PBDEs) are widely used as flame retardants in consumer goods, such as plastics, electronics, textiles, and construction material. PBDEs have been found in human milk, fat, and blood samples. Rodent studies indicate that PBDEs may be detrimental to neurodevelopment, possibly by lowering thyroid hormone concentrations in blood. In the present study, we determined c...

BACKGROUND Persistent organic pollutants (POPs) are developmental toxicants, but the impact of both maternal and paternal exposures on offspring birth size is largely unexplored. OBJECTIVE We examined associations between maternal and paternal serum concentrations of 63 POPs, comprising five major classes of pollutants, with birth size measures. METHODS Parental serum concentrations of 9 or...

introduction: neonatal jaundice is the most common cause of hospitalization.animal study demonstrated a decrease in serum bililrubin level after zinc treatment in hyperbilirubinemic rats. the objective of this study was the investigation of serum zinc level in the neonates with idiopatic .   materials and methods: a case-control study was undertaken on 263 neonates in a neonatal intensive care ...