During the development of Xenopus laevis, maternal mRNAs and proteins stored in the egg direct early patterning events such as the specification of the dorsoventral axis and primary germ layers. In an expression screen to identify maternal factors important for early development, we isolated a truncated cDNA for maternal Zic2 (tZic2), encoding a zinc-finger transcription factor. The predicted t...

In a longitudinal study with 73 mothers and their second-born child, stability and main-level differences between measures of maternal sensitivity across settings and over time were examined. Furthermore, the predictability of harsh discipline by these different maternal sensitivity measures was studied. Maternal sensitivity was assessed at three and six months during bathing, free play on moth...

I used the 2000 and 2005 Ethiopian Demographic and Health Surveys to analyze the effect of maternal education and its pathways on chronic and acute malnutrition in Ethiopia. The pathways examined in this study are socioeconomic status, maternal health-seeking behavior, maternal knowledge of health and family planning and reproductive behavior. I find that maternal education works through all ex...

OBJECTIVE The purpose of this study was to determine the compliance rate with a maternal risk-factor-based guideline for the prevention of neonatal group B streptococcal (GBS) sepsis. METHODS In August 1994, a risk-factor-based guideline for selective intrapartum prophylaxis against neonatal GBS was adopted by a group model health maintenance organization. This guideline identified the follow...

Studies of factor-VIll-related activities were performed in 62 obligate carriers of hemophilia A. comparing 23 daughters of hemophilic men (paternal carriers) with 39 mothers of hemophilic Sons whose fathers were normal by history (maternal carriers). Nineteen of the maternal carriers were mothers of at least 2 hemophiliacs and 20 were mothers of one. but from families whose other close male me...

Adverse early-life conditions induce persistent disturbances that give rise to negative emotional states. Therefore, early life stress confers increased vulnerability to substance use disorders, mainly during adolescence as the brain is still developing. In this study, we investigated the consequences of maternal separation, a model of maternal neglect, on the psychotropic effects of cocaine an...

Maternal exposure to increased synthetic glucocorticoids (GC) during pregnancy is known to disturb fetal development and increase the risk of long-term disease. Maternal exposure to elevated levels of natural GC is likely to be common yet is relatively understudied. The placenta plays an important role in regulating fetal exposure to maternal GC but is itself vulnerable to maternal insults. Thi...

BACKGROUND Studies have shown that maternal depression during pregnancy predicts offspring depression in adolescence. Child maltreatment is also a risk factor for depression. AIMS To investigate (a) whether there is an association between offspring exposure to maternal depression in pregnancy and depression in early adulthood, and (b) whether offspring child maltreatment mediates this associa...

We aim to review available literature related to the telemonitoring of maternal health care for a comprehensive understanding of the roles of Medical Cyber-Physical-Systems (MCPS) as cutting edge technology in maternal risk factor management, and for understanding the possible research gap in the domain. In this regard, we search literature through google scholar and PubMed databases for publis...

Effective screening for the development of early onset preeclampsia (PE) can be provided in the first-trimester of pregnancy. Screening by a combination of maternal risk factors, uterine artery Doppler, mean arterial pressure, maternal serum pregnancy-associated plasma protein-A, and placental growth factor can identify about 95% of cases of early onset PE for a false-positive rate of 10%.