Both imprinting and maternal effects could lead to parent-of-origin patterns in complex traits of human disorders. Statistical methods that differentiate these two effects and identify them simultaneously by using family-based data from retrospective studies are available. The usual data structures include case-parents triads and nuclear families with multiple affected siblings. We develop a li...

improvements in science and technology and the use of modern machinery in manufacture have led to increase in the number of workers exposed to hazardous agents including noise. this study evaluated the effects of occupational noise on hearing loss and blood pressure in welders after 4 years.in this cohort study, all of the welders working at one of neyshabur's water heater producing factories w...

background: health benefits of vitamin d has been proved by a large number of studies, however, to the best of our knowledge there has been no study investigating the effect of mega dose of vitamin d on gestational diabetes mellitus (gdm). this study was the first to assess the effect of postpartum injection of mega dose of vitamin d on blood pressure (bp) in gdm. methods: this is a randomized ...

objectives this study aimed to assess the prevalence and outcome of undiagnosed hypertensive patients admitted to the emergency department. materials and methods this cross-sectional study was conducted from march 2009 to march 2010 at imam hossein medical and educational center, teheran, iran. a total of 2070 patients aged 18 years and older were admitted to the emergency department without pr...

background: no comprehensive study has been conducted on risk factors of sexual dysfunction in women with diabetes mellitus. objectives: the aim of this study was to consider all possible influencing variables including hormonal, physical and, psychological status, socioeconomic status, and dietary intake to get more accurate and reliable results. patients and methods: sexual function was asses...

OBJECTIVE Pregnancy is a period of considerable change in blood pressure, with an early pregnancy decrease followed by a late pregnancy rise. High blood pressure in pregnancy is associated with adverse perinatal outcomes for the mother and offspring. We aimed to define normal ranges of blood pressure across gestation. METHODS We used repeated antenatal blood pressure measurements [median (int...

It is now widely accepted that a gross change in the maternal diet during pregnancy results in offspring with raised blood pressure. More recently, results from human intervention studies and a range of animal experiments have questioned this concept. It thus appears that, when blood pressure is measured directly or by telemetry, the extent to which blood pressure is raised is largely dependent...

Maternal salt and fat intake can independently programme adult cardiovascular status, increasing risk of cardiovascular disease in offspring. Despite its relevance to modern western-style dietary habits, the interaction between increased maternal salt and fat intake has not been examined. Female virgin Sprague-Dawley rats were fed, a standard control diet (CD) (10% kcal fat, 1% NaCl), High-fat ...

BACKGROUND Hypertensive disorders of pregnancy result in significant maternal morbidity and mortality. State and national guidelines have been proposed to increase treatment of patients with hypertensive emergencies or critically elevated blood pressures. There are limited data available to assess the impact of these recommendations on maternal morbidity. OBJECTIVE The purpose of this prospec...