The Japanese Center for the Validation of Alternative Methods (JaCVAM) was established in 2005 to promote the use of alternatives to animal testing in regulatory studies, thereby replacing, reducing, or refining the use of animals, according to the Three Rs principles. JaCVAM assesses the utility, limitations and suitability for use in regulatory studies, of test methods needed to determine the...

1NASA Langley Research Center 2NASA Johnson Space Center 3 College of William and Mary 4 Old Dominion University 5 Christopher Newport University 6 Lawrence Berkeley National Laboratory Introduction Methods by which radiation shielding is optimized need to be developed and materials of improved shielding characteristics identified and validated. The GCR are very penetrating and the energy absor...

Fusion power plant operation will strongly depend on the economy and reliability of crucial components, such as first wall modules, tritium breeding blankets and divertors. Their operating temperature shall be high to accomplish high plant efficiency. The materials properties and component fabrication routes shall also assure long reliable operation to minimize plant outage. The components must...

Background: Epidemiological studies are shown robust association between human papillomavirus (HPV) and cervical cancer. From 1990 HPV was known as a necessary but insufficient cause of cervical invasive cancer. The purpose of this study was to evaluate the cost effectiveness of HPV test in cervical cancer screening. Materials and Methods: This is a systematic review article; the newest scienti...

This work is focused on testing biological samples under conditions as close as possible to the natural environment. The data generated can be used to better understand joint damage mechanisms (e.g., osteoarthritis), improve implants, and as a guide for the design of biomimetic materials. Mechanical testing of biological materials is a continuously developing fi eld that requires the testing of...

The objective of this chapter is to provide an overview of novel non-destructive testing methodologies for bonding quality assessment in glued laminated timber developed within a recently completed Swiss National Science Foundation research project (Sanabria, 2012). The focus is set on air-coupled ultrasound testing, which has previously been applied to wood-based panels typically up to 50 mm t...

This paper presents a review of the principal developments in functionally graded materials (FGMs) with an emphasis on the recent work published since 2000. Diverse areas relevant to various aspects of theory and applications of FGM are reflected in this paper. They include homogenization of particulate FGM, heat transfer issues, stress, stability and dynamic analyses, testing, manufacturing an...

Extensive test data exist on the ignitability of nonmetallic materials in pure oxygen, but these characteristics are not as well understood for lesser oxygen concentrations. In this study, autogenous ignition temperature testing and pneumatic impact testing were used to better understand the effects of oxygen concentration on ignition of nonmetallic materials. Tests were performed using oxygen ...