The production process of an active pharmaceutical ingredient (API) by fermentation in an industrial environment was analysed using process analytical technologies. The Food and Drug Administration’s (FDA) process analytical technology (PAT) initiative is intended to be a collaborative effort with industry to promote the integration of new manufacturing technologies into pharmaceutical producti...

In this study we propose a manufacturing control framework based on radio-frequency identification (RFID) technology and a distributed information system to construct a mass-customization production process in a loosely coupled shop-floor control environment. On the basis of this framework, we developed RFID middleware and an integrated information system for tracking and controlling the manufa...

a manufacturing process cannot be released to production until it has been proven to be stable. also, we cannot begin to talk about process capability until we have demonstrated stability in our process. this means that the process variation is the result of random causes only and all assignable or special causes have been removed. in complicated manufacturing processes, such as drilling proces...

Process Analytical Technology (PAT) is a system for design, analysis, and control of manufacturing processes, based on continuous monitoring/rapid measurements of critical quality and performance attributes of raw material, intermediates and products. PAT involves measurement science by using conventional process sensors such as pressure, temperature and pH probes, as well as novel analyzer tec...

this paper presented a mixed integer programming for integrated scheduling and process planning. the presented process plan included some orders with precedence relations similar to multiple traveling salesman problem (mtsp), which was categorized as an np-hard problem. these types of problems are also called advanced planning because of simultaneously determining the appropriate sequence and m...