Transmembrane adaptor protein PAG, also known as Csk-binding protein (Cbp), which binds and activates the cytoplasmic tyrosine kinase Csk, the major negative regulator of Src-family kinases, was found to be expressed in germinal centers of lymphoid follicles as well as in follicular, but not mantle cell lymphomas. Expression of PAG may reflect its role in regulation of proliferation and differe...

706 haematologica | 2015; 100(6) The 2008 WHO classification described 36 different types of mature B-cell neoplasms, encompassing provisional entities and subtypes. Histological and molecular findings, as well as profound differences in clinical behavior, warrant such a detailed classification. Moreover, even within single lymphoma entities a considerable heterogeneity in disease presentation ...