HIGH MANNOSE-BINDING LECTIN WITH PREFERENCE FOR THE CLUSTER OF α1-2 MANNOSE FROM THE GREEN ALGA BOODLEA COACTA IS A POTENT ENTRY INHIBITOR OF HIV-1 AND INFLUENZA VIRUSES Yuichiro Sato *, Makoto Hirayama*, Kinjiro Morimoto, Naoki Yamamoto, Satomi Okuyama and Kanji Hori From the Faculty of Pharmacy, Yasuda Women’s University, 6-13-1 Yasuhigashi, Asaminami, Hiroshima 731-0153, Japan, the Graduate ...

Lectins are capable of cell agglutination by interacting with the surface exposed glycans. that agglutinate erythrocytes called hemagglutinin. These compounds occur in various organisms including plants. In this study, twenty edible vegetables were subjected to screen for haemagglutination and lectin activity. Lectin activity was assessed measuring inhibition ability different sugars. PBS (Phos...

Mannose-binding lectin (MBL; also known as mannan-binding lectin) is involved in first-line defence by binding to bacteria, viruses, protozoa and helminths through a pattern-recognition mode of detection and then initiating a range of host responses. Currently, we have been unable to extrapolate from what we know of the biochemistry of MBL binding to predict accurately the interaction of MBL wi...

Mannose-binding lectin (MBL) mediates protection against infections by using the complement system, but certain microorganisms may increase infectivity by exploiting this host defense system. Thus, it has been speculated whether genetically determined low MBL levels may confer partial protection against certain intracellular microorganisms, such as Mycobacterium tuberculosis. We investigated MB...

Complement plays a significant role in mediating endothelial injury following oxidative stress. We have previously demonstrated that the lectin complement pathway (LCP), which is initiated by deposition of the mannose-binding lectin (MBL), is largely responsible for activating complement on endothelial cells following periods of oxidative stress. Identifying functional inhibitors that block MBL...

BACKGROUND Human ficolin 2 (encoded by FCN2) and mannose-binding lectin (encoded by MBL2) bind to specific pathogen-associated molecular patterns, activate the complement lectin cascade in a similar manner, and are associated with several infectious diseases. Our recently published study established certain FCN2 promoter variants and ficolin-2 serum levels as protective factors against schistos...