نتایج جستجو برای: mannose 1 phosphate guanyltransferas
تعداد نتایج: 2826486 فیلتر نتایج به سال:
Abbreviations: Bio-LC-ATB-BMPA, 4,4-O-[2-[ 2-[2-[2-[2-[6-(biotinylamino)hexanolyl]amino]ethoxy]exoxy]ethoxy]-4-(1-azi2,2,2-trifluoroethyl)benzoyl]amino-1,3-propanediyl]bis-D-mannose; HES, HEPES, EDTA sucrose; KRH buffer, Krebs-Ringer Hepes buffer; KHB, Krebs-Henseleit bicarbonate; PBS, phosphate-buffered saline; TBS-T, Tris-buffered saline, 0.1% Tween; Carboxy-SNARF-1, 5-(and 6-)carboxy-semi-na...
Quantitative assay and subcellular distribution of enzymes acting on dolichyl phosphate in rat liver
To establish on a quantitative basis the subcellular distribution of the enzymes that glycosylate dolichyl phosphate in rat liver, preliminary kinetic studies on the transfer of mannose, glucose, and N-acetylglucosamine-1-phosphate from the respective (14)C- labeled nucleotide sugars to exogenous dolichyl phosphate were conducted in liver microsomes. Mannosyltransferase, glucosyltransferase, an...
In a previous publication (l), data were reported concerning n-mannose and n-ribose isolated from Torula utilis yeast which had been grown on n-glucose-l-C’4 as the sole source of carbon. It was found that water extraction of the lyophilized yeast yielded a mannan that was completely devoid of radioactivity. Further, the D-ribose obtained from the purine ribosides of the nucleic acid fraction s...
Receptor-mediated uptake of mannose-terminated glycoproteins by macrophages is blocked by treating the cells with swainsonine, an inhibitor of alpha-mannosidase II, and by castanospermine, an inhibitor of the endoplasmic reticulum processing enzyme alpha-glucosidase. Both inhibitors are known to cause accumulation of unprocessed oligosaccharide chains terminating in mannose. Inhibition of ligan...
Glycoproteins containing the mannose 6-phosphate (Man-6-P) modification represent a class of proteins of considerable biomedical importance. They include over sixty different soluble lysosomal hydrolases and accessory proteins, deficiencies of which result in over forty different known human genetic diseases. In addition, there are patients with lysosomal storage diseases of unknown etiology an...
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