IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...

In most formulations processed via continuous twin screw granulation microcrystalline cellulose (MCC) and/or lactose are used as excipients, but mannitol is also a preferred excipient for wet granulation and tableting due to its non-hygroscopicity and inertness. Therefore, the aim of the current study was to investigate the influence of process parameters on critical quality attributes of granu...

STUDY OBJECTIVES To compare the sensitivity and validity of mannitol, histamine, and cold air challenges to demonstrate the effect of inhaled corticosteroids (ICS) in asthma. DESIGN A prospective study. PARTICIPANTS Seventeen patients with recently diagnosed, steroid-naive asthma who fulfilled the diagnostic criteria of Finnish Social Insurance Institution and were hyperresponsive to both m...

1* Associate Professor, Dept of Neurosurgery, Mamata Medical College, Khammam, Telangana 2 Assistant Professor, Dept of Neurosurgery, Sidhartha Medical College, Vijayawada, Andhra Pradesh *Corresponding Author Jagadeesh Babu. K Associate Professor, Department of Neurosurgery, Mamata Medical College, Khammam, Telangana, Email: [email protected], Phone no: 8374590275 Abstract Medical mana...

Using the pH-sensitive fluorescent dye BCECF, we compared the effects of hyperosmotic urea on basolateral Na(+)/H(+) exchange (NHE) with those of hyperosmotic mannitol in isolated nonperfused proximal tubule S2 segments from mice lacking both the mdr1a and mdr1b genes (KO) and wild-type (WT) mice. All the experiments were performed in CO(2)/HCO-free HEPES solutions. Osmolality of the peritubula...

Seed germination is generally the critical step in seed establishment and thus determination of successful crop production. This study was focused at examination biochemical parameters effected by low water potential which generated polyethylene glycol (PEG) 6000 mannitol, related to drought stress growth Waha durum wheat genotype. Two tests were carried out a chamber; first comprises into Petr...

Using the canine thalamic infarction model, we have investigated the effects of 10 ml/kg of 20% mannitol on the hemodynamics of the ischemic brain. Mannitol was found to cause an increase in rCBF, but it is not marked in animals with severe ischemic foci. Increases were statistically significant in the animals with moderate ischemia. Increases in rCBF due to mannitol administration lasted for a...