In the present study, a novel series of Mannich bases of 3-substituted 5-(pyridin-4-yl)-1,3, 4-oxadiazol-2-thione derivatives were synthesized. Docking study was performed to rationalize the possible interactions between the synthesized compounds and active site of 14DM. The test compounds were screened for antimycobacterial activity using Middlebrook 7H9 medium against M. tuberculosis H37Rv (A...

This research includes synthesis of new derivatives benzimidazole , the compound (A1*) prepared by reaction o-phenylene diamine with carbon disulfide in alcoholic potassium hydroxide. Then was ethyl chloroacetate and hydroxide to give ester (A2*). preparation hydrazide (A3*) (A2*) hydrazine hydrate (80%). we used prepare pyrazole (A4), then mannich basses (A4) different primary aromatic amines ...

Aim: A variety of Paracetamol derivatives as mannich bases were prepared through mannich reaction by reacting Paracetamol as compound containing active hydrogen, substituted benzaldehyde, morpholine as secondary amine compound and small amount of conc. HCl as catalyst. A simplistic one-pot method under mild conditions has been developed for the synthesis of all the compounds and they were chara...

A series of Mannich bases having piperidine moiety were reacted with 2-mercaptoethanol, leading to 1-aryl-3-piperidine-4-yl-1-propanone hydrochlorides. The cytotoxicity and carbonic anhydrase inhibitory activities of these new compounds were evaluated. Among the compounds, only one derivative, nitro substituent bearing EU9, showed an effective cytotoxicity, although weak tumor specificity again...

Inhibition of acetylcholinesterase and butyrylcholinesterase (AChE and BuChE) as two major forms of cholinesterases (ChEs) is considered as the common approach for the treatment of Alzheimer's disease (AD). The present study was done to explore the anticholinesterase inhibition property of coumarin Mannich base derivatives. A series of cumarin Manich bases were synthesized (4a-h) through one-po...

A catalytic Mannich reaction of a simple ester with no activating functionality at the α-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Brønsted base-catalyzed Mannich reaction of unactivated esters as substrates.

Resistance to chemotherapeutic agents is a major obstacle in cancer treatment. A recently proposed strategy target the collateral sensitivity of multidrug resistant (MDR) cancer. Paradoxically, toxicity certain metal chelating increased, rather than decreased, by function P-glycoprotein (Pgp), which known confer resistance effluxing compounds from cells. We have characterized and compared solut...