Most conventional statistical tests for analyzing RT-qPCR data require normalization before differential expression can be assessed. This normalization can have a substantial effect on the interpretation and validity of the statistical test, but this effect is often ignored. Therefore the uWMW test, as proposed in [1], extends the Wilcoxon–Mann–Whitney test so that the normalization is incorpor...

MOTIVATION Recently, De Neve et al. proposed a modification of the Wilcoxon-Mann-Whitney (WMW) test for assessing differential expression based on RT-qPCR data. Their test, referred to as the unified WMW (uWMW) test, incorporates a robust and intuitive normalization and quantifies the probability that the expression from one treatment group exceeds the expression from another treatment group. H...

An accurate and early diagnosis of the Alzheimer’s Disease (AD) is of fundamental importance for the development of effective treatments to palliate the effects of the disease. Computer Aided Diagnosis (CAD) allows physicians to detect early stages of the disease, and functional brain images have been proved to be very useful in this task. This paper presents a new CAD system that consists of t...

Over a quarter-century ago, Alan Agresti (Biometrics, 1980) proposed using the generalized odds ratio (genOR) to summarize the association between two ordinal variables. Unfortunately, genOR is still largely unknown, even though it is elegantly straightforward and fills key voids in the working statistician’s toolbox. An extension of it, a statistic we are calling “WMWodds,” is an ideal effect-...

It is crucial to adapt and improve the (primary) health care systems of countries to prepare for future patient profiles and their related needs. The main aim of this study was to acquire a comprehensive overview of the perceptions of primary care experts in Singapore about the state of primary care in Singapore, and to compare this with the state of primary care in other countries. Notwithstan...

We present a general method for extracting the Gell Mann-Low logarithmic derivative of an e ective charge of an observable directly from data as a mean for empirically verifying the universal terms of the QCD -function. Our method avoids the biases implicit in tting to QCD-motivated forms as well as the interpolation errors introduced by constructing derivatives from discrete data. We also deri...

BACKGROUND Transketolase-like 1 (TKTL1) induces glucose degradation through anaerobic pathways, even in presence of oxygen, favoring the malignant aerobic glycolytic phenotype characteristic of tumor cells. As TKTL1 appears to be a valid biomarker for cancer prognosis, the aim of the current study was to correlate its expression with tumor stage, probability of tumor recurrence and survival, in...