background and aims. head and neck tumors are the most common complaints of people referring to different medical sections, especially in children. the aim of this study was to evaluate the prevalence of these tumors in children less than 12 years of age to provide a better perspective for future studies. materials and methods. all the files in department of pathology at tabriz pediatric hospit...

Teratomas are germ cell tumors. Mediastinum is the second most common extra-gonadal site of these tumors.[1-3] Mediastinal masses in children and adolescents are usually considered malignant. Even benign teratomas have been reported to transform to malignant ones in case of delayed diagnosis or presentation.[3-5] Moreover, large mediastinal teratoma without any long-term symptomatology is quite...

Malignant germ cell tumors are rare tumors of the childhood accounting for less than 3 % of pediatric malignancies. Endodermal sinus tumor (EST) is the most common histologic subtype of malignant GCT. The vagina is an extremely rare site for GCTs [1]. They are usually diagnosed before 3 years of age. Historically, the approach to therapy has included radical surgical resection with adjuvant irr...

malignant germ-cell tumors (mgct) are rare tumors of childhood accounting for less than 3% of pediatric malignancies. endodermal sinus tumor (est) forms the most common histologic subtype of mgct. the vagina is an extremely rare site for gcts. an 8-month-old female was admitted with a short history of vaginal bleeding, and a mass protruding from the vagina. she was pale and a mass was palpable ...

Malignant germ cell tumors (GCT) of childhood are rare and heterogeneous neoplasms thought to arise from primordial germ cells. They vary substantially in their natural history and show important clinical differences from their adult counterparts. To address the biological basis for these observations, we have undertaken a comprehensive analysis of global gene expression patterns in pediatric m...

Abstract Background Swyer syndrome (Pure gonadal dysgenesis, 46 XY) is a rare form of disorder sexual development. These patients presented with external female phenotype, normal Mullerian structures and streak gonads. Pure XY are more likely to develop germ cell tumors due the presence Y chromosome. Case presentation A 19-year-old patient phenotype primary amenorrhea. Clinical examination, Kar...

This study was aimed to investigate the clinical characteristics, treatment and prognosis effect of malignant ovarian germ cell tumors (MOGCTs). A total of 39 patients with MOGCTs treated at Gynecology Obstetrics in Tianjin Central Hospital were enrolled from January 1999 to November 2009 in this study. All the patients underwent pathological examination and diagnosis was confirmed. We used uni...

Primary germ cell tumors of extragonadal origin are rare and exact incidence of this type cancer is unknown. They have been estimated to represent 3-5% of all adult germ cell malignancies (1). The origin of primary extragonadal germ cell tumors (EGGCT) is still a matter of debate. According to widely accepted theory, during embryogenesis, germ cells are misplaced anywhere at the midline. The me...

BACKGROUND Germ-cell tumors (GCT) are a histologically and biologically diverse group of neoplasms which primarily occur in the gonads but also develop at different extragonadal sites in the midline of the body. The head and neck region including the upper respiratory tract is a very rare location for such tumors in both children and adults, which can cause diagnostic and therapeutic difficulti...

Malignant ovarian germ cell tumors (OGCTs) include immature teratomas (ITs), dysgerminomas (DGs), endodermal sinus tumors (ESTs), choriocarcinomas, and embryonal carcinomas. Knowledge about the genetic changes associated with malignant OGCT development is sparse. We therefore analyzed 25 OGCTs (12 DGs, 4 ESTs, and 9 ITs) for gains and losses by comparative genomic hybridization. In total, more ...