Angiotensin (ANG) II-dependent hypertension is characterized by increases in intrarenal ANG II levels, derangement in renal hemodynamics, and augmented tubular sodium reabsorptive capability. Increased nephron expression of renin-angiotensin system components, such as angiotensinogen by proximal tubule cells and renin by collecting duct principal cells, has been associated with an augmented abi...

Tripeptides isoleucyl-prolyl-proline (IPP) and valyl-prolyl-proline (VPP) act as ACE inhibitors in vitro. Double transgenic rats (dTGR) harbouring human renin and human angiotensinogen genes develop malignant hypertension due to increased angiotensin II formation. The present study was aimed to evaluate possible antihypertensive effect of IPP and VPP in this severe model. Four-week-old dTGR wer...

BACKGROUND We attempted to review the clinical and fundus findings in patients with malignant hypertension (MHT). METHODS Charts and fundus photographs of patients with malignant hypertensive retinopathy from 1995 to 2000 were retrospectively reviewed. Data of patients were included when their color fundus photographs revealed findings suggestive of malignant hypertension (MHT). There had to ...