At a certain moment in life everyone has to make important decisions with direct implications for their future. This time has now arrived and I would like to announce that, as of 1 January 2017, I will be stepping down as Editorin-Chief of the Netherlands Heart Journal (NHJ). Formally, the appointment of an Editor-in-Chief is a matter for both the Publisher and the Netherlands Society of Cardio...

1 Acknowledgements The work in this thesis 1 is a part of the OtaOnline research project at the Helsinki University of Technology. I would like to take the opportunity to thank all those who have contributed to the work. First, I would like to express my gratitude to my supervisor Prof. Shosta Sulonen for all his support, guidance, constructive criticism and ideas. I would also like to thank my...

The finding of raised growth hormone concentrations in patients with secondary malignancy in the liver is reported. These concentrations were significantly higher than those found in patients with primary malignancy only or in those with non-hepatic secondaries. A wide range of malignancies was investigated and the high growth hormone concentration was not specific for any type of tumour. This ...

The treatment of Cancer is far from being satisfactory. It cannot be eradicated without the damage of the normal and healthy parts. It is usually destructive to the healthy tissue, and often to the whole individual, excision by surgery or destruction by chemotherapy and radiation, weaken the immune system of the body and often do more harm than good. The treatment of Cancer is either by surgery...

Secretion by tumor cells of circulating bone-resorbing factors may frequently underlie the hypercalcemia that occurs in patients with malignancy. Efforts to identify the responsible mediators have been hampered by a lack of available human tumor cell systems suitable for study of the pathogenesis of the humoral hypercalcemia syndrome. We have established a transitionalcell carcinoma (TCC) line ...

In 25 years, 18 patients with breast cancer were treated at St Jude Children's Research Hospital, 16 were female and 2 were male. The patients presented with primary malignancy (2), metastatic disease (13), or secondary malignancy (3). One of the females with primary breast malignancy had alveolar rhabdomyosarcoma. She was treated with wide excision and is currently receiving chemotherapy. The ...

CASE REPORT. A 46year old man presented with a three month history of hiccup, occurring almost daily but associated only with the swallowing of solid food. It usually settled with a glass of water, the longest attack lasting almost thirty minutes. Indeed, it was this attack which precipitated his referral. On careful questioning at the time and retrospectively, he denied any dysphagia whatsoeve...

(58 articles) Reviews in Translational Hematology • (4217 articles) Neoplasia • (149 articles) Genomics • (1086 articles) Gene Expression • Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this article in parts or in its entirety may be found online at: htt...

BACKGROUND Malignant tumours of the duodenum are rare and often difficult to diagnose. Due to the small clinical experience with duodenal malignancies their prognosis is unknown and resection is the treatment of choice. CASE REPORT Adding to a small series of incidental tumours, we report the case of a 65-year-old patient with primary extranodal (MALT-) lymphoma of the duodenum infiltrating t...

Gynecologic malignancy during pregnancy is a stressful problem. For the diagnosis and treatment of malignancy during pregnancy, a multidisciplinary approach is needed. Patients should be advised about the benefits and risk of treatment. When selecting a treatment for malignancy during pregnancy, the physiologic changes that occur with the pregnancy should be considered. Various diagnostic proce...