BACKGROUND TO THE DEBATE Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This debate examines whether enough evi...

Malaria is a major threat to public health and economic development in Africa. Current estimates indicate that at least one to three million children die of malaria each year in Africa alone. Efforts to eradicate malaria have failed and parasite resistance to the most commonly used and affordable anti-malarial drugs is developing rapidly. Insecticide resistance in the vector is also an evolving...

Malaria is one of the most common major health problems all over the world. Pharmacotherapy is the most common treatment strategy for the disease. But, the main obstacle behind this is emergence of resistance for many of these drugs. Hence, to overcome this problem, the major option available since ancient times is medicinal plants all over the world. Mankind is blessed with wide range of herba...

OprF, the major outer membrane (OM) protein of Pseudomonas aeruginosa, has been proposed to be comprised of a series of beta-strands separated by periplasmic or surface-exposed loop regions. In this study, a simple malarial epitope was used to demonstrate that OprF can be used as an expression vector to present foreign peptide sequences, namely, the 4-amino-acid (aa) repeating epitope (Asn-Ala-...

BACKGROUND TO THE DEBATE Current guidelines recommend that all fever episodes in African children be treated presumptively with antimalarial drugs. But declining malarial transmission in parts of sub-Saharan Africa, declining proportions of fevers due to malaria, and the availability of rapid diagnostic tests mean it may be time for this policy to change. This debate examines whether enough evi...

Malaria is the most important parasitic disease of man. It is the protozoan infection of RBCs transmitted by bite of blood feeding female anopheline mosquito. Until the 19th century malaria was found throughout Europe, North America and Russia. Since then, it has been eradicated from these areas but in tropics though initial efforts of eradication had been successful, there has been resurgence ...