artemisinin and its derivatives are very important new class of antimalarial drugs. one of the most important artemisinin derivatives is artemether. the antiparasitic activity of artemether as a derivative of artemisinin is related to endoperoxide bridge in its structure. the aim of this study was the evaluation of antileishmanial effect of artemether, with more focus on its apoptotic effect. i...

due to the limited availability of effective pharmaceutical products and serious side effects of the available therapy for leishmaniasis, search for useful medicinal plants is necessary. previous studies reported preventative effect of echinacea against leishmania infections through immunologic stimulation. here we tested concentrated ethanolic extract of the root of echinacea purpurea prepared...

background: although the association between major depressive disorder (mdd) and low self-esteem is well established, we do not know if race and ethnicity modify the magnitude of this link. objectives: using a nationally representative sample of adults in the united states, we explored whether or not race alters the association between mdd and self-esteem. materials and methods: data came from ...

buccoadhesive drug delivery systems have distinct advantages in comparison with oral administration. plant exudates like gum or mucilage are being studied for their use as pharmaceutical adjuvant. the aim of this study is to evaluate the properties of the plantago major seed mucilage as a mucoadhesive agent and propranolol hydrochloride is chosen as a model drug. mucoadhesive tablets of propran...

objective: the current study was conducted to compare the efficacy and side effects of bifrontal electrode placement with standard bitemporal electrode placement in the treatment of patients with major depression. method: eighty nine patients with major depression were treated with a course of bifrontal or bitemporal ect. all patients received 8 sessions of ect treatment; and the hamilton ratin...

herein, a 28-year-old man with hoarseness, skin and oral lesions is presented. at the time of admission, the patient had an erythematous plaque on his chin near his lower lip and an erythematous-violaceous plaque on his palate near the open-ing of the pharynx and 20 kg weight lost in last one year. the biopsy of his skin lesions by hematoxylin and eosin staining revealed an infiltration of the ...

introduction: there are limited reports about selenium status in major thalassemia patients. the aim of this study is evaluation of selenium status in patients with major thalassemia south east of iran with large sample size and wide range of age. this study compared selenium status with other sites of the world. methods: in this study 369 cases that had major thalassemia for more than 5 years ...

background pcr is a molecular technique for herpes simplex virus (hsv) detection that can cause life-threatening infections such as encephalitis and keratitis. however, the main issues, false-negative results causing by pcr inhibitors, of this technique that reduce pcr efficiency. to overcome this problem, a competitive internal amplification control (iac) was constructed for conventional pcr u...

abstract objective thalassemia major is a severe transfusion-dependent anemia that needs iron chalation therapy to remove iron overload. the objectives of the present study were to assess the iron overload liver response to inulin of chicory supplementation by evaluating the serum ferritin and liver enzymes. methods among 70 beta thalassemia patients, 50 were selected for chelating therapy usin...