Enzyme and or hormone actions have not been shown to be consistently changed by consuming a low-magnesium diet similar to one that may occur in the general population. Thus, a human metabolic study was performed to determine whether deficient intakes of magnesium similar to those that occur naturally have pathophysiological effects through altering calcium retention and the metabolism of other ...

OBJECTIVE An inverse relationship between serum magnesium concentration and vascular calcification has been reported following observational clinical studies. Moreover, several studies have been suggesting a protective effect of magnesium on the vascular calcification. However, the exact mechanism remains elusive, and investigators have speculated among a myriad of potential actions. The effect...

The relationship between total and ionic serum magnesium in health and chronic disease across different ethnicities has not been well studied. Accordingly, we have examined the interrelationship between total magnesium and ionic magnesium, as well as ionic calcium to ionic magnesium ratio, in 286 patients made up of indigenous and non-indigenous Australians, with or without diabetes. Significan...

Magnesium is an essential nutrient for muscle, cardiovascular, and bone health on Earth, and during space flight. We sought to evaluate magnesium status in 43 astronauts (34 male, 9 female; 47 ± 5 years old, mean ± SD) before, during, and after 4-6-month space missions. We also studied individuals participating in a ground analog of space flight (head-down-tilt bed rest; n = 27 (17 male, 10 fem...

Evidence suggests that magnesium deficiency may play an important role in cardiovascular disease. In this study, we evaluated the effects of a magnesium infusion and dietary-induced isolated magnesium deficiency on the production of thromboxane and on angiotensin II-mediated aldosterone synthesis in normal human subjects. Because insulin resistance may be associated with altered blood pressure,...

implicated the importance of magnesium ion in the pathophysiology of migraine.1,2 Magnesium has been also administered for both prophylactic and acute therapy in migraine, but the question of its efficacy has not been studied adequately.3,4 So the aim of this study was to evaluate the effects of oral magnesium oxide supplementation associated with routine treatments of migraine seizures. In thi...

The growth of cells of Escherichia coli has been studied in media with varying amounts of magnesium. Experiments in which the content of magnesium in the medium and in the cell have been directly measured reveal that the growth rate of magnesium-limited wild type cells is half-maximal at extracelhrlar concentrations of 1 to 3 X low6 M. Mutants have been isolated which require 100 times this con...

T HREE experiments were conducted with eight gestating Angus cows to study the effects of feeding different magnesium levels at 145,200 and 255 days gestation. Each trial consisted of a S-day adjustment period and a 10-day experimental period. The average daily magnesium intake for the cows fed the basal ration was 3.4 grams. Supplemental magnesium was added at levels of 0, 4.1, 8.2 and 16.4 g ...

The N-(benzoylphenyl)-1H-indole-2-carboxamide derivatives 1-6 were synthesized, and the lipid-lowering effects of two of these novel compounds were studied using hyperlipidemic rats as an experimental model. Treatment of ethyl-1H-indole-2-carboxylate with aminobenzophenones in the presence of sodium ethoxide and DMF, followed by purification using column chromatography, gave the target compound...

BACKGROUND Among hospitalized patients, indications for the measurement of magnesium levels and treatment of hypomagnesemia with intravenous magnesium are not well defined. Recently, there have been reports of worldwide shortages of intravenous magnesium sulphate. OBJECTIVE To examine secular trends in the administration of intravenous magnesium on hospital wards at a tertiary care institutio...