Glioblastoma multiforme (GBM), which account for more than 50% of all gliomas, is among the deadliest of all human cancers. Given the dismal prognosis of GBM, it would be advantageous to identify early biomarkers of a response to therapy to avoid continuing ineffective treatments and to initiate other therapeutic strategies. The present in vivo longitudinal study in an orthotopic mouse model de...

Amide proton transfer (APT) imaging may potentially detect mobile proteins/peptides non-invasively in vivo, but its specificity may be reduced by contamination from other confounding effects such as asymmetry of non-specific magnetization transfer (MT) effects and spin-lattice relaxation with rate R1 (=1/T1). Previously reported spillover, MT and R1 correction methods were based on a two-pool m...

We previously developed a negatively charged amino acid dendrimer to address the safety concerns associated with the constituent unit of these systems, which resulted in the formation of a sixth-generation glutamic acid-modified dendritic poly(L-lysine) system (KG6E). The aim of this study was to develop a nanocarrier for targeted drug delivery into cancer cells. In this study, we have synthesi...

BACKGROUND Atopic dermatitis (AD) is frequently associated with food allergies. In addition to the skin prick test (SPT) and serum-specific IgE, the atopy patch test (APT) has been introduced as a diagnostic procedure for food allergies. OBJECTIVE Our aim was to evaluate the diagnostic value of the APT, the SPT and the serum-specific IgE levels compared with that of oral food challenge test a...

The rapid and continuous progress in trace analysis of metals is associated with development of several new techniques such as spectrophotometry. Thiosemicarbazones have been used as chromogenic reagents in spectrophotometric determination of metals. In this study the synthesis and characterization of pyridoxal thiosemicarbazone (PDT) and 2-acetyl pyridine thiosemicarbazone (2-APT) using IR, MS...

BACKGROUND There is still a lack of standardization of the atopy patch test (APT) in test procedures and evaluation methods. Our aim was to examine the reproducibility of APT results and to compare visual evaluation to chromametry and laser Doppler imaging. METHODS Fifty-two volunteers with atopic eczema/dermatitis syndrome (AEDS) were included. The APT was performed on tape-stripped and unst...

Period detection from time series is an important problem with many real-world applications such as weather forecast, stock market predictions, electrocardiogram analysis, periodic disease outbreak. In this work, we present a novel approximate period detection method for time series. The simplicity of our algorithm and its adaptability for high dimensional datasets using renowned tools and tech...

LINKED CONTENT This article is linked to Talley et al papers. To view these articles, visit https://doi.org/10.1111/apt.16372 and https://doi.org/10.1111/apt.16401

LINKED CONTENT This article is linked to Khanna & Camilleri papers. To view these articles, visit https://doi.org/10.1111/apt.16143 and https://doi.org/10.1111/apt.16290

Amiodarone (A) is a widely-used antiarrhythmic drug. Pulmonary toxicity is the most serious adverse effect with an estimated mortality of 1 to 33 percent. In order to determine an element helpful for diagnosis, we examined four patients with amiodarone-induced pulmonary toxicity, three patients treated with A, without evidence of pulmonary toxicity but with a main underlying pulmonary disease, ...