Hemophagocytic lymphohistiocytosis (HLH) is a rare and potentially fatal disorder characterized by abnormal activation of macrophages and occurring in many conditions in all age group. It is also characterized by hemophagocytosis in the bone marrow and in the reticuloendothelial system (RES). The underlying mechanism of acquired HLH is associated with uncontrolled inflammatory reaction which in...

Backgrond: Hemophagocytosis (HS) is an interesting finding that observed in bone marrow, lymph nodes, CSF other reticuloendothelial systems but at times overlooked or not incorporated reports. Demonstration of hemophagocytosis one criterion the diagnosis Hemophagocytic Lymphohistiocytosis (HLH).
 Aims and Objective: as important evaluated pediatric marrows having different clinical diagnos...

Background Early diagnosis of macrophage activations syndrome (MAS) in systemic juvenile idiopathic arthritis (sJIA) may be challenging because it may mimic the clinical features of the underlying disease or be confused with an infectious complication. However, the diagnostic value of the guidelines for hemophagocytic lymphohistiocytosis (HLH) (1) or sJIA-associated MAS (2) has seldom been exam...

Introduction Hemophagocytic Lymphohistiocytosis (HLH) is a rare histiocyte disorder associated with perforin-dependent cytotoxic function, characterized by a highly stimulated, but ineffective, immune response to antigens, which results in life-threatening cytokine storm and inflammatory reaction. Both familial and secondary forms have been described. Secondary HLH in associated with infections...

Gamma-delta T-cell lymphomas (GD-TCL) are rare and rapidly fatal neoplasms that are often associated with Hemophagocytic Lymphohistiocytosis (HLH), a syndrome of fevers, cytopenias, and multiorgan failure that often leads to a rapid death. We report the first case demonstrating an association between GD-TCL, HLH, and cardiac amyloidosis, presenting a novel mechanism for rapid deterioration in t...