نتایج جستجو برای: lymphocyte associated antigen 4 ctla
تعداد نتایج: 2795929 فیلتر نتایج به سال:
Objective: To summarize and compare the therapeutic efficacy of programmed death 1 (PD-1) and cytotoxic T lymphocyte associated antigen 4 (CTLA-4) pathway inhibitors in the treatment of non-small-cell lung cancer (NSCLC). Methods: Traditional and network meta-analysis of clinical phase II/III randomized controlled trials of PD-1 and CTLA-4 pathway inhibitors vs. controls (general chemotherapy o...
Background: Cytotoxic T-lymphocyte-associated antigen 4 (CTLA-4) is a transmembrane protein on the activated T-cell surface. It can inhibit T-cell proliferation and activation and it increases tumor susceptibility. Some reports have associated CTLA-4 +49A>G polymorphism with certain cancers, but the associations with lung cancer have been inconsistent. Therefore, we aimed to investigate the ass...
Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) functions as a negative regulator of endogenous and vaccine-induced antitumor immunity. The administration of fully human anti-CTLA-4 blocking monoclonal antibodies to advanced-cancer patients increases immune-mediated tumor destruction in some subjects. Nonetheless, patients that respond also frequently manifest serious inflammatory patholog...
BACKGROUND Cytotoxic T lymphocyte associated antigen-4 (CTLA-4) is involved in the activation pathways of T lymphocytes. It has been shown that the circulating form of CTLA-4 is elevated in patients with hymenoptera allergy and can be down regulated by immunotherapy. OBJECTIVE to assess the effects on CTLA-4 of venom immunotherapy, given with different induction protocols: conventional (6 wee...
We had formerly demonstrated that subjects chronically infected with Trypanosoma cruzi show impaired T cell responses closely linked with a process of T cell exhaustion. Recently, the expression of several inhibitory receptors has been associated with T cell dysfunction and exhaustion. In this study, we have examined the expression of the cytotoxic T lymphocyte antigen 4 (CTLA-4) and the leukoc...
The objective of this case-control study was to extensively explore the relationship of Cytotoxic T-lymphocyte antigen-4 (CTLA-4) tagging polymorphisms with susceptibility to non-small-cell lung cancer (NSCLC). We recruited 521 sporadic NSCLC cases and 1,030 non-cancer controls. The genotypes of CTLA-4 rs16840252 C>T, rs231775 G>A, rs3087243 G>A and rs733618 T>C polymorphisms were evaluated usi...
Cytotoxic T lymphocyte antigen 4 (CTLA-4) is a T cell costimulation receptor that delivers inhibitory signals upon activation. Although the tyrosine-based motif ((165)YVKM) within its cytoplasmic tail has been shown to associate in vitro with Src homology 2 domain-containing tyrosine phosphatase (SHP-2) and phosphatidylinositol 3 kinase upon phosphorylation, the mechanism of negative signaling ...
Background: Immunological factors are important in pregnancy loss because of the interaction between mother and fetus. T-regulatory cells as the component of humeral immune response play important role in the fetu-maternal interface. One of the regulatory mechanisms for these cells is mediated by antigen independent co -stimulatory signals and interaction of Cytotoxic T-Lymphocyte Antigen 4 (B7...
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