introduction: breast cancer is the most common cancer in women worldwide and her-2 is one importantly prognostic factor in this cancer. tumor markers use as a criterion for predicting recurrence, but in breast cancer physical examination and mammography are important factors that are recommended for following up the recurrence. the aim of this study was to assess the correlation between breast ...

background: considering molecular target therapy concept in the treatment of oral squamous cell carcinoma (oscc), many attempts have been performed to introduce an effective molecular marker during recent years. several investigations have emphasized on the role of cd44 in various cancers and few studies have mentioned cd24 and cd74. the purpose of this study was to investigate the relationship...

Inhibition of VEGF signaling can promote lymph node metastasis in preclinical models, but the mechanism is not fully understood, and successful methods of prevention have not been found. Signaling of hepatocyte growth factor (HGF) and its receptor c-Met can promote the growth of lymphatics and metastasis of some tumors. We sought to explore the contributions of c-Met signaling to lymph node met...

PURPOSE To explore the relationship between morphological characteristics and histologic localization of metastasis within sentinel lymph nodes (SLN) and axillary spread in women with breast cancer. METHODS We selected 119 patients with positive SLN submitted to complete axillary lymph node dissection from July 2002 to March 2007. We retrieved the age of patients and the primary tumor size. I...

Mediastinal lymph node metastasis from colorectal cancer is rare, and barely any reports have described resection of this pathology. We report herein a successful thoracoscopic resection of mediastinal lymph node metastasis in a prone position. A 65-year-old man presented with posterior mediastinal lymph node metastasis after resection of the primary rectal cancer and metachronous hepatic metas...

BACKGROUND By clarifying the significance of clinicopathological factors for retroperitoneal lymph node metastasis and survival of patients with endometrial cancer, we suggest ideas for optimal treatment of this disease. METHODS A retrospective study was conducted in 310 women with endometrial cancer who underwent surgery with retroperitoneal lymphadenectomy. To evaluate retroperitoneal lymph...

BACKGROUND The purpose of this study was to determine the incidence, risk factors, and prognostic significance of level VI lymph node metastases from hypopharyngeal squamous cell carcinoma (SCC). METHODS A retrospective review of 68 previously untreated patients with hypopharyngeal SCC who underwent level VI node dissection was performed. RESULTS Level VI lymph node metastases occurred in 2...

1Department of Oncology, Lombardi Comprehensive Cancer Center, Georgetown University, 3800 Reservoir Road NW, Washington, DC 20007, USA 2Clinical Breast Care Project, 620 Seventh Street, Windber, PA 15963, USA 3Division of Oncogenomics, Department of Pathology, University of Regensburg, Franz-Josef-Strauß-Allee 11, 93053 Regensburg, Germany 4Department of Pathology, University of Milan School o...