A semi-automatic procedure to correlate the motion of lung tumor points in 4D-CT images with a respiratory surrogate signal is presented. Data analysis was performed to characterize of the robustness of external/internal correlation properties in the clinical framework of gated radiotherapy treatments. A cross-correlation based algorithm was implemented to perform template matching for tracking...

Respiratory motion causes uncertainties in tumor edges on either computed tomography (CT) or positron emission tomography (PET) images and causes misalignment when registering PET and CT images. This phenomenon may cause radiation oncologists to delineate tumor volume inaccurately in radiotherapy treatment planning. The purpose of this study was to analyze radiology applications using interpola...

Introduction Dynamic contrast-enhanced (DCE) MRI has proven valuable to characterize tissue of interest in solitary pulmonary nodule (SPN) [1], especially for delineating malignant from benign tumor. In DCE MRI studies, the kinetics of signal variation at lesions following the administration of the contrast agent is analyzed from time-intensity curve. Thus, it is crucial to measure the signal i...

Objective(s): To investigate the role of miR-22 in the efficacy of combined icotinib (BPI-2009H) and pemetrexed (LY-231514) on tumor growth and apoptosis in rats with non-small cell lung cancer (NSCLC).Materials and Methods: Rats were injected with HCC827 cells, which were transfected with anti-miR-22, followed by the treatment of BPI-20...

The uncertain position of lung tumor during radiotherapy compromises the treatment effect. To effectively control respiratory motion during radiotherapy of lung cancer without any side effects, a novel control scheme, hypnosis, has been introduced in lung cancer treatment. In order to verify the suggested method, six volunteers were selected with a wide range of distribution of age, weight, and...

Objective(s): Lung cancer is the main leading cause of cancer death worldwide. Angiogenesis is the main step in proliferation and spreading of tumor cells. Targeting vascular endothelial growth factor (VEGF) is an effective approach for inhibition of cancer angiogenesis. Nanobodies (NBs) are a novel class of antibodies derived from the camel. Unique characteristics of Nbs like their small size ...

We propose a new markerless tracking technique of lung tumor motion by using an X-ray fluoroscopic image sequence for real-time image-guided radiation therapy (IGRT). A core innovation of the new technique is to extract a moving tumor intensity component from the fluoroscopic image intensity. The fluoroscopic intensity is the superimposition of intensity components of all the structures passed ...

For PET/CT, fast CT acquisition time can lead to errors in attenuation correction, particularly at the lung/diaphragm interface. Gated 4D PET can reduce motion artifacts, though residual artifacts may persist depending on the CT dataset used for attenuation correction. We performed phantom studies to evaluate 4D PET images of targets near a density interface using three different methods for at...

In inverse planning of lung radiotherapy, techniques are required to ensure dose coverage of target disease in the presence of tumor motion as a result of respiration. A range of published techniques for mitigating motion effects were compared for dose stability across 5 breath cycles of ±2 cm. Techniques included planning target volume (PTV) expansions, internal target volumes with (OITV) and ...

Motion-adaptive radiotherapy techniques are promising to deliver truly ablative radiation doses to tumors with minimal normal tissue exposure by accounting for realtime tumor movement. However, a major challenge of successful applications of these techniques is the realtime prediction of breathing-induced tumor motion to accommodate system delivery latencies. Predicting respiratory motion in re...