Longitudinal data were analysed on the lung function of 25 of 29 survivors of childhood leukaemia or lymphoma, who had been conditioned with cyclophosphamide and total body irradiation before allogeneic bone marrow transplantation, to test whether children are particularly vulnerable to pulmonary damage after transplantation. None developed chronic graft-versus-host disease. Transfer factor and...

The first lung transplantation was performed 50 years ago, in 1963, in Jackson, Mississippi and the first long-term survivals were achieved 25 years ago. Currently, lung transplantation has been established as an effective therapy for a group of selected patients with advanced-stage lung diseases, when other therapeutic options are no longer useful and there is no other alternative therapy. Pre...

Pediatric lung diseases remain a costly worldwide health burden. For many children with end-stage lung disease, lung transplantation remains the only therapeutic option. Due to the limited number of lungs available for transplantation, alternatives to lung transplant are desperately needed. Recently, major improvements in tissue engineering have resulted in newer technology and methodology to d...

Idiopathic pulmonary fibrosis (IPF) is a progressive, fatal disease that can only be cured by lung transplantation. Pharmacological agents play a role in preserving lung function and prolonging survival until a suitable donor organ becomes available. However, data on the effects of newer antifibrotic therapies on lung transplantation outcomes in IPF patients are lacking. The nine patients inclu...

the treatment of lung transplant recipients: an analysis of200 consecutive procedures. Chest 1992; 102:1049-54 2 Garnty ER, McCabe M, Husain A, et al. The utility of transbronchial biopsies after isolated lung transplantation. Chest 1992; 102:73S 3 Solans EP, Garrity ER, McCabe M, et al. Early diagnosis of cvtomegalovirus pneumonitis in lung transplant patients. Arch Pathol Lab Med 1995; 119:33...

A 44 year old patient with end stage idiopathic pulmonary fibrosis underwent single left lung transplantation. A perfusion lung scan performed 13 days after transplantation revealed deficient perfusion in the transplanted lung. Pulmonary angiography showed severe pulmonary artery anastomotic stenosis. Percutaneous insertion of a balloon expandable stent improved both pulmonary perfusion and res...

Coronary artery disease has historically been a contraindication to lung transplantation. We report a successful combined bilateral lung transplantation and off-pump coronary artery bypass in a 62-year-old man. The patient had a progressive decline in lung function due to idiopathic pulmonary fibrosis and a history of severe occlusive coronary artery disease.

OBJECTIVES Lung transplantation (LTx) is the only effective treatment for end-stage lung disease. In rapidly deteriorating patients awaiting transplant, supportive strategies for lung function allow only a short period of support and lung transplantation remains the definitive therapy. An urgent transplant programme may reduce the waiting time, allowing lung transplantation in these patients. ...