In this paper, we investigate the properties of the cell-graphs by using the spectral graph theory. The spectral analysis is performed on (i) the adjacency matrix of a cell-graph, and (ii) the normalized Laplacian of the cell-graph. We show that the spectra of the cell-graphs of cancerous tissues are unique and the features extracted from these spectra distinguish the cancerous (malignant gliom...

Patients with severe emphysema have a higher risk of developing lung cancer, and their surgical risk increases when emphysema is accompanied by a giant bulla. Here, we describe a patient who had an emphysematous giant bulla in the right upper lobe that was treated with an endobronchial valve placement. Subsequently, a cancerous lesion on the contralateral lung was successfully removed by lobect...

Abstract The effects observed under near-infrared laser irradiation of mammalian cells have been demonstrated to depend a large extent on the type source. In our experiments, we measured concentration reactive oxygen species in cell cultures different origin (rodent and human, cancerous non-cancerous) exposed radiation low-level lasers at 1265 nm. Surprisingly, narrowband occur be more pronounc...

OBJECTIVE To explore the key regulatory genes associated with lung cancer in order to reduce its occurrence and progress through silencing these key genes. METHODS To identify the key regulatory genes involved in lung cancer, we performed a combination of gene array and bioinformatics analyses to compare gene transcription profiles in 3 monoclonal cell strains with high, medium or low metasta...

As a regulator of coagulation, abnormal Protein Z (PZ) expression may lead to the formation of blood clots in humans. While previous studies have shown that PZ protein is altered in several types of cancer, however, additional observations are needed to understand the complex biology involved. Herein, we investigated local alterations in PZ expression in lung adenocarcinomas by measuring gene a...

The discovery that the herbicide paraquat was selectively accumulated by the lung, both in vivo and in vitro, in comparison with other tissues, provided an explanation for its selective toxicity to the lung. This uptake process is energy dependent and obeys saturation kinetics. A characterization of the process led to the identification of endogenous chemicals that are the natural substrates fo...

BACKGROUND The aim of this study was to investigate the effects of poly-lactic-co-glycolic acid (PLGA) nanotopographies with alginate or chitosan protein preadsorption on the functioning of healthy and cancerous lung and breast cells, including adhesion, proliferation, apoptosis, and release of vascular endothelial growth factor (VEGF), which promotes tumor angiogenesis and secretion. METHODS...

Lung cancer screening identifies cancers with heterogeneous behaviors. Some lung cancers will be identified among patients who had prior negative CT screens and upon follow-up scans develop a de novo nodule that was determined to be cancerous. Other lung cancers will be identified among patients who had one or more prior stable positive scans that were not determined to be lung cancer (indeterm...

The current carcinogenicity study with female rats focused on the toxicity and carcinogenicity of intratracheally instilled fine and ultrafine granular dusts. The positive control, crystalline silica, elicited the greatest magnitude and progression of pulmonary inflammatory reactions, fibrosis and the highest incidence of primary lung tumors (39.6%). Addition of poly-2-vinylpyridine-N-oxide dec...

evaluation of serum albumin level and its effect on prognosis in patients admitted to intensive care unit    valizadeh hasanloei ma [1] , norozinia h [2] *, shateri k [3] , bakhtyari l [4] , hosseinpour h [5]     received: 18 sep , 2013 accepted: 21 nov , 2013   abstract   background & aims : albumin and globulin are the largest components of the body proteins. albumin is a protein made in the ...