This article presents a historical overview along with the general characteristics of lysergic acid diethylamide (LSD). The increasingly popular new derivatives LSD were also included. Their changing legal status over time was presented, followed by an attempt to interpret mass spectrum analysing fragmentation pathways molecule using 1P-LSD as example. Attention paid method sample preparation, ...

31483]{ p i.p. dlmethyt'__m_'/Aldrich/ and/Sigma-Chem./ cf. !LSD' = Delysid chron. _' tolerance influence on 'reflex-motive' food-rewarding bar pressing rat /XXXII/ J.Pharmacoi.Exp.Ther. 197, No.3, 495-502 /1976/ Kovacic B, Domino E F /Detroit and Ann Arbor,Mich.,USA/ Tolerance and Limited Cross-Tolerance to the Effects of N,NDimethyltryptamine (DMT) and Lyserglc Acid Diethylamlde-Z5 /LSD) on F...

Previous deep learning-based line segment detection (LSD) suffers from the immense model size and high computational cost for prediction. This constrains them real-time inference on computationally restricted environments. In this paper, we propose a light-weight detector resource-constrained environments named Mobile LSD (M-LSD). We design an extremely efficient architecture by minimizing back...

Hallucinogens, including mescaline, psilocybin, and lysergic acid diethylamide (LSD), profoundly affect perception, cognition, and mood. All known drugs of this class are 5-HT(2A) receptor (2AR) agonists, yet closely related 2AR agonists such as lisuride lack comparable psychoactive properties. Why only certain 2AR agonists are hallucinogens and which neural circuits mediate their effects are p...

Histone modifications mediate changes in gene expression by altering the underlying chromatin structure or by serving as a binding platform to recruit other proteins. One such modification, histone methylation, was thought to be irreversible until last year when Shi and co-workers broke new ground with their discovery of a lysine-specific histone demethylase (LSD 1). They showed that LSD 1, a n...

In order to determine the distribution and function of the 5-HT5A serotonin receptor subtype, we generated knockout mice lacking the 5-HT5A gene. Comparative autoradiography studies of brains of wild-type (wt) and 5-HT5A knockout (5A-KO) mice revealed the existence of binding sites with high affinity for [125I]LSD that correspond to 5-HT5A receptors and that are concentrated in the olfactory bu...