BACKGROUND To explore potential interrelationships between lipoprotein-associated phospholipase A2 (Lp-PLA2), the metabolic syndrome (MetS), and incident cardiovascular disease (CVD). METHODS AND RESULTS MetS was defined by the National Cholesterol Education Program Adult treatment Panel III criteria in 4480 nondiabetic Malmö Diet and Cancer Study subjects without history of CVD. Incidence of...

Microvascular functions have been shown to be sensitive to agents associated with changes in cyclic nucleotide levels. The central hypothesis of the current study was that one measure of capillary exchange capacity, hydraulic conductivity (Lp), would be elevated by agents shown to elevate cellular levels of cGMP. To evaluate the hypothesis, frog mesenteric capillary Lp was measured during lumin...

OBJECTIVES This study sought to examine the role of lipoprotein-associated phospholipase A₂ (Lp-PLA₂/PLA2G7) in human inflammation and coronary atherosclerosis. BACKGROUND Lp-PLA₂ has emerged as a potential therapeutic target in coronary heart disease. Data supporting Lp-PLA₂ are indirect and confounded by species differences; whether Lp-PLA₂ is causal in coronary heart disease remains in que...

Elevated levels of lipoprotein(a) (Lp(a)) have been identified as an independent risk factor for coronary heart disease. Plasma Lp(a) levels are reduced by monoclonal antibodies targeting proprotein convertase subtilisin/kexin type 9 (PCSK9). However, the mechanism of Lp(a) catabolism in vivo and the role of PCSK9 in this process are unknown. We report that Lp(a) internalization by hepatic HepG...

Let M be the Doob maximal operator on a filtered measure space and let v an Ap weight with 1<p<+∞. We try proving that ∥Mf∥Lp(v)≤p′[v]Ap1p−1∥f∥Lp(v), where 1/p+1/p′=1. Although we do not find approach which gives constant p′, obtain ∥Mf∥Lp(v)≤p1p−1p′[v]Ap1p−1∥f∥Lp(v), limp→+∞p1p−1=1.

For 0 < p < 1, Haberl and Ludwig defined the notions of symmetric and asymmetric Lp-intersection bodies. Recently, Wang and Li introduced the general Lp-intersection bodies. In this paper, we give the Lp-dual geominimal surface area forms for the extremum values and Brunn-Minkowski type inequality of general Lp-intersection bodies. Further, combining with the Lp-dual geominimal surface areas, w...

OBJECTIVES To investigate if serum Lp(a) lipoprotein (Lp(a)), a risk factor for atherosclerotic diseases, increases in patients with gout, who frequently also have atherosclerotic disease. METHODS Fasting blood samples were taken for measurement of Lp(a) and other variables in 175 male patients with primary gout. Serum concentrations of Lp(a) were measured by enzyme linked immunosorbent assay...

Although dendritic cells (DCs) located in the small intestinal lamina propria (LP-DCs) migrate to mesenteric lymph nodes (MLNs) constitutively, it is unclear which chemokines regulate their trafficking to MLNs. In this study we report that LP-DCs in unperturbed mice require CCR7 to migrate to MLNs. In vitro, LP-DCs expressing CCR7 migrated toward CCL21, although the LP-DCs appeared morphologica...

objective febrile convulsion is the most common benign convulsive disorder in children. meningitis is one of the most important causes of fever and convulsions, diagnosed by lumbar puncture (lp), a painful and invasive procedure much debated  regarding its necessity. this study evaluates the frequency of abnormal lp findings in a group of patients, to determine whether or not unnecessary lp can...