Long-term potentiation in the spinal dorsal horn requires peptidergic C-fibre activation in animals. Perceptual correlates of long-term potentiation following high-frequency electrical stimulation in humans include increased sensitivity to electrical stimuli at the high frequency stimulation site (homotopic pain-long-term potentiation) and increased sensitivity to pinprick surrounding the high ...

I hope my NMDA receptors were working well in the 1980s as I try to recall the events leading up to the establishment of the mechanism of induction of LTP. My story begins in 1980 as I start my first postdoctoral position in the laboratory of Hugh McLennan, in Vancouver. Hugh was interested in l-glutamate as a neurotransmitter in the brain and was one of the pioneers in the identification of mu...

One of the most significant challenges in neuroscience is to identify the cellular and molecular processes that underlie learning and memory formation. The past decade has seen remarkable progress in understanding changes that accompany certain forms of acquisition and recall, particularly those forms which require activation of afferent pathways in the hippocampus. This progress can be attribu...

campus can be depotentiated by low-frequency stimulation. 5-HT4 receptors are expressed in the hippocampus and are suggested to be involved in hippocampus-dependent cognitive processes. Since the role of these receptors in the dentate gyrus has yet not been characterized, this study investigated the effects of 5-HT4 receptors on basal synaptic transmission, LTP and depotentiation in the dentate...

The hippocampus communicates with the neocortex via the entorhinal cortex. These areas are thought to be critically involved in the consolidation of memories. The hippocampus is considered to be the site of association of sensory information, which is then laid down for long-term storage in the neocortex. We examined the projection from the subiculum to the entorhinal cortex to determine whethe...