نتایج جستجو برای: long qt syndrome
تعداد نتایج: 1359864 فیلتر نتایج به سال:
BACKGROUND Mutations in SCN5A can result in both long QT type 3 (LQT3) and Brugada syndrome (BrS), and a few mutations have been found to have an overlapping phenotype. Long QT syndrome is characterized by prolonged QT interval, and a prerequisite for a BrS diagnosis is ST elevation in the right precordial leads of the electrocardiogram. METHODS AND RESULTS In a Danish family suffering from l...
About 300 loss-of-function mutations in the IKs channel have been identified in patients with Long QT syndrome and cardiac arrhythmia. How specific mutations cause arrhythmia is largely unknown and there are no approved IKs channel activators for treatment of these arrhythmias. We find that several Long QT syndrome-associated IKs channel mutations shift channel voltage dependence and accelerate...
Antzelevitch C. Role of spatial dispersion of repolarization in inherited and acquired sudden cardiac death syndromes. Am J Physiol Heart Circ Physiol 293: H2024–H2038, 2007. First published June 22, 2007; doi:10.1152/ajpheart.00355.2007.— This review examines the role of spatial electrical heterogeneity within the ventricular myocardium on the function of the heart in health and disease. The c...
BACKGROUND Recent molecular biological investigations have identified abnormal genes in familial forms of long QT syndrome, but in bradycardia dependent acquired long QT syndrome, no such genetic abnormality has yet been identified. OBJECTIVE To investigate the relation between the responses of QT interval to pacing change and to disopyramide. METHODS This study included 13 patients with br...
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