Gene identification represents the first step to a better understanding of the physiological role of the underlying protein and disease pathways, which in turn serves as a starting point for developing therapeutic interventions. Familial hypercholesterolemia is a hereditary metabolic disorder characterized by high low-density lipoprotein cholesterol levels. Hypercholesterolemia is a quantitativ...

genetic diversity of red jabal barez red goat population was studied based on eight microsatellite markers consist bm1312, maf64, ilsts034, ilsts059, orafcb20, il2ra, lscv24 and lscv11. blood sample extracted of 100 red jabal barez goats were randomly collected from 10 farms and dna was isolated using the diatom dna prep kit. the pcr reactions were successfully done and all loci showed suitable...

In the recent years, many protocols aimed at reproducibly sequencing reduced-genome subsets in non-model organisms have been published. Among them, RAD-sequencing is one of the most widely used. It relies on digesting DNA with specific restriction enzymes and performing size selection on the resulting fragments. Despite its acknowledged utility, this method is of limited use with degraded DNA s...

association of genetic polymorphism in the calpastatin (cast) gene with average daily gain was examined in iranian purebred kurdi sheep. the genotypes for cast were determined by the pcr-sscp method. blood samples were collected from 84 purebred kurdi sheep belonging to the kurdi breeding station located in the khorasan province, north-east of iran. extraction of genomic dna was based on the gu...

A method for recognition of Persian handwritten digits based on characterization loci and mixture of experts is proposed. This method utilizes the characterization loci, as the main feature. In the classification stage of our proposed method the mixture of experts are applied. This recognition method is applied to Farsi hand-written digits in the HODA database. The experimental results support ...

As a necessary step in construction of elliptic matrix models, which preserve the superintegrability property ?char, we suggest an deformation peculiar loci pk?n, play important role precise formulation this property. The suggestion is to define pk?n-loci as functions with right asymptotics at ??i?. If hypothesis correct, one can move substituting Schur and Macdonald characters by GNS stu...

The present work develops a methodology for the detection of outliers in functional data, taking into account both their shape and magnitude. Specifically, multivariate method anomaly called Local Correlation Integral (LOCI) has been extended adapted to be applied particular case using calculation distances Hilbert spaces. This validated with simulation study its application real data. taken sc...

DNA hypermethylation is common and plays a critical role in the regulation of gene expression. It is considered a major cause of carcinogenesis. High-throughput profiling method has been developed to analyze the methylation status of hundreds of pre-selected genes simultaneously. The aim of this study was to analyze promoter hypermethylation profiles of each subtype of ovarian epithelial cancer...

We describe a multilocus, marker-based regression method for inferring interactions between genes controlling inbreeding depression in self-fertile organisms. It is based upon selfing a parent heterozygous for several unlinked codominant markers, then analyzing the fitness of progeny marker genotypes. If loci causing inbreeding depression are linked to marker loci, then viability selection is m...