Although high levels of tumor-infiltrating lymphocytes (TILs) generally correlate with good prognosis in high-grade serous ovarian cancer (HGSC) patients, little is known about the phenotype or specificity of these cells. We have recently demonstrated that TIL expressing the intra-epithelial lymphocyte marker CD103 (official name, integrin αE, ITGAE) abundantly infiltrate HGSCs, strongly correl...

To realize the self-healing concept of smart grids, an accurate and reliable fault locator is a prerequisite. This paper presents a new fault location method for active power distribution networks which is based on measured voltage sag and use of whale optimization algorithm (WOA). The fault induced voltage sag depends on the fault location and resistance. Therefore, the fault location can be f...

Metastatic cell heterogeneity presents a significant obstacle to the development of targeted molecular and immunotherapeutics. Profiling of melanocyte differentiation antigens has revealed a nonstochastic, site-specific pattern of expression in metastases that was highest in brain, intermediate in soft tissues/lymph nodes, and lowest in visceral sites. Site-specific antigen heterogeneity, thus,...

We present a modified native chromatin immunoprecipitation sequencing (ChIP-seq) experimental protocol compatible with a Gaussian mixture distribution based analysis methodology (nucleosome density ChIP-seq; ndChIP-seq) that enables the generation of combined measurements of micrococcal nuclease (MNase) accessibility with histone modification genome-wide. Nucleosome position and local density, ...

Hubs are critical elements of transportation networks. Location of hubs and allocation of demands to them are of high importance in the network design. The most important purpose of these models is to minimize the cost, but path reliability is also another important factor which can influence the location of hubs. In this paper, we propose a P-center hub location model with full interconnection...