Telomerase RNAs (TERs) are highly divergent between species, varying in size and sequence composition. Here, we identify a candidate for the telomerase RNA component of Leishmania genus, which includes species that cause leishmaniasis, a neglected tropical disease. Merging a thorough computational screening combined with RNA-seq evidence, we mapped a non-coding RNA gene localized in a syntenic ...

abstract thymic carcinoid is an uncommon neoplasm that can present with cushing syndrome. we report a 39-year old woman with symptoms of cushing syndrome secondary to thymic carcinoid and synchronous with tuberculous lymphadenitis and pulmonary tuberculosis.

Lymphadenitis is the most common extrapulmonary manifestation of tuberculosis. It remains both diagnostic and therapeutic challenge because it mimics other pathologic processes and yields inconsistent physical and laboratory findings. Diagnosis is difficult often requiring biopsy. A thorough history and physical examination, staining for acid-fast bacilli, fine-needle aspiration and PCR are hel...

Indrani Dhawan 1 , Oneal Gupta 1 , Ankit Kaushik* 1 , Sunil Ranga 1 , Dimple Kasana 2 , Prem R Gupta 1 1 Department of Pathology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India 2 Department of Microbiology, Vardhman Mahavir Medical College and Safdarjung Hospital, New Delhi, India Background: Tuberculosis (TB) is the leading cause of death from a curable infectious d...

Triosephosphate isomerase (TIM) is a key enzyme in glycolysis that catalyses the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate. This simple reaction involves shuttling protons mediated by protolysable side chains. The catalytic power TIM thought to stem from its ability facilitate deprotonation carbon next carbonyl group generate an enediolate intermediate. interm...