Accumulating evidences indicate that cancer-related lncRNAs occur frequent somatic copy number alternation (SCNA). Although individual SCNA lncRNAs have been implicated in tumor biology, their regulatory mechanism has not been assessed in a systematic way. In order to explore the expression characteristics and biological functions of SCNA lncRNAs in cancer, we built a computational framework ba...

Noncoding RNAs (ncRNAs) have been demonstrated to closely associate with gene regulation and encompass the well-known microRNAs (miRNAs), as well as the most recently acknowledged long noncoding RNAs (lncRNAs). Current evidence indicates that lncRNAs can interact with miRNAs and these interactions play crucial roles in cancer metastasis, through regulating critical events especially the epithel...

اهتفاقثو اهرخفو ةملأا ةيأ ةيوه نم أزجتي لا اءزج يرامعملا ثارتلا لكشي . ةيخيراتلا ةرامعلا رصانع نا يف اهؤانبو اهميمصت مت دق ةيملاسلإا تابلطتمل يويحو لاعف لكشب ةباجتسلاا ىلع ةرداق نوكت ثيحب يضاملا ةينيدلاو ةيسفنلاو ةيعامتجلااو ةيئيبلاو ةيداملا سانلا . رضاحلا تقولا يف نويرامعملا نوسدنهملا موقي رصانعلا ذخأب اوذخأي ام ةداعو ميمصتلا عيراشم يف اهلاخدا و ةيملاسلإا ةيخيراتلا ينابملا نم ةفلتخملا نيوكت ر...

Background: In recent years, LncRNA acts as a member of competing endogenous RNA (ceRNA), playing an important role in drug resistance lung cancer. The aim this study was to identify potential biomarkers about cisplatin resistant cancer cells using comprehensive ceRNA network. Methods: GSE6410 (GPL-201) analyzed gene expression changes A549 NSCLC cells. GSE43249 (GPL-14613) included noncoding p...

Background: Endothelial cell (EC) maladaptation to disturbed blood flow at predilection sites of atherosclerosis is characterized by inflammation and defective regeneration. The RNase Dicer is essential for the production of microRNAs, which play a crucial role in EC maladaptation. EC-derived Dicer promotes atherosclerosis and suppresses KLF4, Notch1, and Wnt signaling. While Dicer increases EC...

زمینه و هدف: microRNA (miRNA) دستة جدیدی از شاخص‌های زیستی‌اند که در سطح سلولی مسیرهای پیام‌رسانی تغییرات ساختاری عملکردی قلبی درگیرند. همچنین تمرینات تناوبی شدید (HIIT) شامل وهله‌های فعالیت ورزشی نسبتاً با مدت زمان کوتاه است دوره‌های بازیافت فعال یا غیرفعال یکدیگر جدا شده‌اند، می‌تواند سبب بهبود آمادگی قلبی-تنفسی متغیرهای فیزیولوژیک متناظر آن افراد سالم شود. ازاین‌رو پژوهش حاضر نظر دارد اثر هشت...

Chordoma is a rare bone tumor with high recurrence rate, but the mechanism of its development is unclear. Long non-coding RNAs(lncRNAs) are recently revealed to be regulators in a variety of biological processed by targeting on mRNA transcription. Their expression profile and function in chordoma have not been investigated yet. In this study, we firstly performed the comprehensive analysis of t...

Long noncoding RNAs (lncRNAs) regulate gene expression by acting with microRNAs (miRNAs). However, the roles of cancer specific lncRNA and its related competitive endogenous RNAs (ceRNA) network in hepatocellular cell carcinoma (HCC) are not fully understood. The lncRNA profiles in 372 HCC patients, including 372 tumor and 48 adjacent non-tumor liver tissues, from The Cancer Genome Atlas (TCGA)...