Nuvan (DDVP) is a member of organophosphorus compounds. It is extremely toxic to insects and is widely used as insecticides. Nuvan has been taken for the acute toxicity to a fresh water fish Channa punctatus LC50 value calculated for the acute toxicity, which were 0.024 ml/L. Histopathological study of kidney and liver after 24hr, 48hr, 72hr and 96hr exposure to acute toxicity of Nuvan. Treatme...

Objective : to assess the subchronic toxicity of bis(3,5-di-tert-butyl-4-hydroxyphenyl)dimethyltin (Me-3) and (3,5-di-tert-butyl-4-hydroxyphenyl)triphenyltin (Me-5) with identification external signs changes in indicators functional state liver kidneys Wistar rats (females) 14-fold daily intragastric injection simulate a metronomic chemotherapy regimen. Materials method study was conducted on 2...

Two 19 year old patients with juvenile chronic arthritis developed liver toxicity during treatment with sulphasalazine. A significant increase in the levels of liver enzymes in serum samples was noticed in relation to the initiation of treatment in one patient and to the increase in dose in the second. The enzymes returned to normal levels 14 days after the drug had been stopped. A rechallenge ...

We describe four children with Dravet syndrome treated with the combination of valproic acid (VPA) and topiramate (TPM) who developed transient liver toxicity. The time-interval between fever, administration of acetaminophen, epileptic status and liver enzyme disturbances in our four cases suggests that accumulation of toxic acetaminophen-metabolites is possibly responsible for liver toxicity. ...

Purpose: Acetaminophen is safe drug but it may cause hepatic failure in high doses. N-acetyl cysteine (NAC) used treatment of acetaminophen intoxication. Resveratrol be experimental intoxication models. Purpose, compare the efficacy NAC and resveratrol treatments intoxication.
 Materials Methods: We 34 rabbits. 6 rabbits were included control group 7 enrolled other groups APAP group, anima...