Liver is the largest vital organ in human body and plays a major role in various metabolism and excretion of xenobiotics within the body. Liver dysfunction is a foremost health problem that challenges not only health care professionals but also the pharmaceutical industry as more than 900 drugs are implicated in case of liver injury. Hepatotoxicity is caused by various toxic substances and cert...

BACKGROUND Farnesoid X Receptor (FXR) is a member of the nuclear receptor superfamily and is a ligand-activated transcription factor essential for maintaining liver and intestinal homeostasis. FXR is protective against carcinogenesis and inflammation in liver and intestine as demonstrated by the development of inflammation and tumors in the liver and intestine of FXR knock-out mice. However, me...

Bielschowsky (2) reported the occurrence of carcinoma in the rat's thyroid gland made hyperplastic by administration of allyl thiourea when the carcinogen, 2-acetaminofluorene (AAF) was administered simultaneously. Applying a similar principle, we investigated the effects of administration of this carcinogen to rats in which hyperplasia of target organs was produced by injection of male and fem...

background: deltamethrin (dm) is a synthetic pyrethroid insecticide which can lead to pathological effects in mammals through oxidative stress. on the other hand, virgin olive oil (voo) is a rich source of phenolic compounds with antioxidants. the aim of the present study was to determine the protective effects of voo against dm-induced hepatotoxicity. methods: thirty-six mice were randomly sep...

OBJECTIVE Liver fibrosis and subsequent cirrhosis is a major cause of death worldwide, but few effective antifibrotic therapies are reported. Whey-hydrolyzed peptide (WHP), a major peptide component of bovine milk, exerts anti-inflammatory effects in experimental models. A WHP-enriched diet is widely used for immunomodulating diets (IMD) in clinical fields. However, the effects of WHP on liver ...

Liver injury is a common pathological basis of various liver diseases, and long-term liver injury is often an important initiation factor leading to liver fibrosis and even liver cirrhosis and hepatocellular carcinoma (HCC). It has been reported that deproteinized extract of calf blood (DECB) can inhibit the replication of hepatitis B virus and confers a protective effect on the liver after tra...

To investigate the protective effect of the leaf extract of Andrographis paniculata (Ap) against ethanol induced liver toxicity in male albino rats. The liver toxicity was induced by the administration of ethanol to the animals at the optimum dosage of 7.9g/kg body wt., orally for 45 days. After induction of liver toxicity the aqueous plant extract of A.p was administered to the animal 250 mg/k...