introduction in this study, we examined the effects of the antibiotics levofloxacin on the liver as well as its devastating effects which are ensued from its over-prescription. levofloxacin serves as one of the antibiotics of genitourinary system and inferior respiratory system. since liver is the foremost organ that receives all the materials absorbed by intestine through the portal vein, and ...

the objectives of this work was to examine the toxicological effect and molecular changes caused by a heavy metal pollutant mercuric chloride (hgcl2), in fresh water snakehead channa punctatus, locally known as taki fish in bangladesh. when fishes were exposed to hgcl2, it induced death of the fishes in a concentration-dependent manner. 1 mm, the highest concentration tested in this study, was ...

The natural course of chronic hepatitis B virus (HBV) infections follows distinct clinical disease phases, characterized by fluctuating levels serum HBV DNA and ALT. immune cells their features that govern these transitions remain unknown. In the current study, we performed RNA sequencing on purified from blood (n = 42) liver 10) healthy controls patients. We found gene expression profiles betw...

Extracellular vesicles (EVs) secreted by stem and progenitor cells have significant potential as cell-free ‘cellular’ therapeutics. Yet, small EVs (<200 nm) are rapidly cleared after systemic administration, mainly the liver, presenting challenges targeting to a specific organ or tissue. Microencapsulation using natural nano-porous hydrogels (microgels) has been shown enhance engraftment increa...

Objective(s): End-stage hepatic failure is a potentially life-threatening condition for which orthotopic liver transplantation is the only effective treatment. However, a shortage of available donor organs for transplantation each year results in the death of many patients waiting for liver transplantation. Xenotransplantation, or the transplantation of cells, tissues, or organs between differe...

Hepatitis B, a common infectious disease of liver, is transmitted by blood and body fluids like semen and vaginal fluid that carry hepatitis B virus (HBV).  In chronic infection, medical care is required to decrease possibility of cirrhosis and liver cancer. In the present report, the hepatoprotective effect of an Echinacea purpurea preparation (Echiherb®) has been described...

liver fibrosis is a potentially reversible response to hepatic insults, triggered by different chronic diseases most importantly viral hepatitis, alcoholic, and non-alcoholic fatty liver disease. in the course of the chronic liver disease, hepatic fibrogenesis may develop, which is attributed to various types of cells, molecules, and pathways. activated hepatic stellate cell (hsc), the primary ...

Objective(s): 3,4-Methylenedioxymethamphetamine (MDMA) is one of the most popular drugs of abuse in the world with hallucinogenic properties that has been shown to induce apoptosis in  liver cells. The present study aimed to investigate the effects of pentoxifylline (PTX) on liver damage induced by acute administration of MDMA in Wistar rat. Materials and Methods: Animals were administered wit...