Dehydroevodiamine (DHE), a natural quinazoline alkaloid used in Chinese herbal medicine, exhibits promising antitumor properties various cancers, including gastric cancer. Glycolysis is essential for tumor proliferation and survival. The effect of DHE on hepatoma cells (hepatocellular carcinoma, HCC) the mechanism underlying glycolytic regulation remain unclear. In this study, cell viability, a...

S-adenosyl methionine (SAM) is a ubiquitous methyl donor that was reported to have chemo- protective activity against liver cancer, however the molecular footprint of SAM is unknown. We show here that SAM selectively inhibits growth, transformation and invasiveness of hepatocellular carcinoma cell lines but not normal primary liver cells. Analysis of the transcriptome of SAM treated and untreat...

hematopoietic stem cell transplantation (hsct) has been practiced for more than 30 years. hematological malignanciesare the main indications for this treatment. however, its indications in adults are different from children.advances in chemotherapy and target therapy have improved treatment outcome of some of the very high riskcancers, and changed indications of hsct in children. multi-center c...

background: cisplatin-based chemotherapy is the standard treatment for advanced non-small cell lung cancer (nsclc). many novel drugs, including gemcitabine, vinorelbine, paclitaxel and docetaxel have been used in combination with cisplatin in this setting. of these drugs, gemcitabine is reported to have a high response rate and acceptable toxicity. the aim of this study was to evaluate the effi...

The development of liver cancer would undergo a sequential progression from chronic inflammatory liver disease, cirrhosis to neoplasia. During these pathophysiological changes, abnormal liver microenvironment might induce the hepatocytes to die, abnormally proliferate and initiate cancer stem cells. Metallocarboxypeptidases (MCPs) involved in multiple biological functions including inflammation...

Liver resection is the mainstay of treatment for patients with primary and metastatic liver tumors. However, a large majority of patients present for initial medical evaluation with primary and metastatic liver tumors when their cancer is unresectable. Several trials have been undertaken to identify alternative treatments and complementary therapies. In the near future, the field of liver surge...

Abstract Objective To report the treatment of a long‐term survival case stage IV lung squamous cell carcinoma (LSCC) patient with multiorgan metastases, including intrapulmonary, brain, liver, bone, and multiple lymph nodes. Methods results A 72‐year‐old male LSCC achieved total 85 months comprehensive chemotherapy, radiotherapy, targeted, immunotherapy. Conclusion Full‐course management, multi...

Consistent liver metastases in animal models is generally observed only with certain cancer cell lines. With the aim of improving on existing animal models of liver metastases, we hypothesized that cancer cells encased in 300 microm microcapsules, mimicking micrometastatic foci, might be effective seeds of liver metastases. A total of 3,000 microcapsules, containing 700 to 1,500 viable cells/ca...

Metastasis is a highly complicated and sequential process in which primary cancer spreads to secondary organic sites. Liver is a well-known metastatic organ from colorectal cancer. Carcinoembryonic antigen (CEA) is expressed in most gastrointestinal, breast, and lung cancer cells. Overexpression of CEA is closely associated with liver metastasis, which is the main cause of death from colorectal...