BACKGROUND Respiratory syncytial virus (RSV) is a leading cause of lower respiratory tract illness (LRTI) in children. Several promising live-attenuated RSV vaccines are in development. Defining additional markers of attenuation could enhance clinical trials. METHODS We used clinical data, virologic data, and nasal wash (NW) specimens from 20 RSV-naive children enrolled in studies of 4 live-a...

The poultry industry depends heavily on immunization, particularly with live attenuated vaccines. These vaccines are commonly not adjuvanted and can be either injected or delivered in birds’ mucosa. In the current study we evaluated protective efficacy of non-adjuvanted Newcastle disease virus (LaSota strain) Three NDV were used to vaccinate three groups chickens. same immunizations administere...

Abstract Mucosal vaccines have the potential to elicit protective immune responses at point of entry respiratory pathogens thus preventing even initial seed infection. Unlike licensed injectable vaccines, mucosal comprising protein subunits are only in development stage. One primary challenges associated with has been identification and characterization safe yet effective adjuvants that can eff...