Studies were designed to explore the association of lipoprotein lipase (LPL) and hepatic triglyceride lipase (HTGL) activities with lipoproteins in human postheparin plasma (PHP). The major peak of LPL activity after gel filtration of PHP eluted after the triglyceride-rich lipoproteins and just before the peak of low density lipoprotein (LDL) cholesterol. When PHP contained chylomicrons, an add...

Knowledge concerning the formation and transport of esterified cholesterol in plasma is fundamental to an understanding of the mechanisms by which cholesterol is delivered to peripheral tissues from the liver and removed from these tissues for recycling or excretion through the liver. Hepatic cholesterol enters the plasma in man predominantly in the unesterified, or free, form as a component of...

lasses of lipoproteins were determined during the course of these injections. A marked increase in concentration of these three classes of lipoproteins occurred during the administration of carl)on tetra(hloride. After the cessation of this drug, the lipoproteins of largest Sf rate returned to normal first with those of lower Sf rate returning to normal levels in the order of decreasing Sf rate...

Epstein-Barr virus (EBV)-induced immortalization of adult human B lymphocytes is suppressed by physiologic concentrations of human plasma lipoproteins. Several inhibitory mechanisms appear to be operative. First, low density lipoproteins (LDL) directly reduce the ability of EBV to transform human B cells. Second, LDL as well as intermediate and very low density lipoproteins modulate early induc...

Epidemiologic studies suggest a link between infection/inflammation and atherosclerosis. During the acute-phase response to infection and inflammation, cytokines induce tissue and plasma events that lead to changes in lipoprotein. Many of these changes are similar to those proposed to promote atherogenesis. The changes of lipoproteins during infection and inflammation are reviewed with a focus ...

Factors reflecting the concentration of high-density lipoproteins in serum were assessed for 108 men and 106 women participating in a Venetian screening program for hyperlipoproteinemia. The methods applied, optimized in our laboratory, were: (a) cholesterol in high-density lipoproteins, determined in the supernate after sedimentation of the very-low-density lipoproteins + low-density lipoprote...

A clear picture of lipoprotein metabolism is essential for understanding the pathophysiology of atherosclerosis. Many students are taught that low-density lipoprotein-cholesterol is "bad" and high-density lipoprotein-cholesterol is "good." This misconception leads to students thinking that lipoproteins are types of cholesterol rather than transporters of lipid. Describing lipoproteins as partic...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...

Submit Manuscript | http://medcraveonline.com Abbreviations: NP: Nano Particle; LDL: Low Density Lipoproteins ; HDL: High Density Lipoproteins ; SLDL: Synthetic Low Density Lipoproteins; LDL-Rl: Low Density Lipoprotein Receptor ; SR-Bi: Scavenger Receptor Class B Type I; DTPA: Diethylene Triaminepenta Acetic Acid; SPECT: Single-Photon Emission Computed Tomography; MRI: Magnetic Resonance Imagin...