Cells of Saccharomyces cerevisiae lacking Apq12, a nuclear envelope (NE)-endoplasmic reticulum (ER) integral membrane protein, are defective in assembly of nuclear pore complexes (NPCs), possibly because of defects in regulating membrane fluidity. We identified BRR6, which encodes an essential integral membrane protein of the NE-ER, as a dosage suppressor of apq12 Delta. Cells carrying the temp...

Intestinal lipid transport plays a central role in fat homeostasis. Here we review the pathways regulating intestinal absorption and delivery of dietary and biliary lipid substrates, principally long-chain fatty acid, cholesterol, and other sterols. We discuss the regulation and functions of CD36 in fatty acid absorption, NPC1L1 in cholesterol absorption, as well as other lipid transporters inc...

Zhang, Junlong, D. I. W. Phillips, Chunli Wang, and Christopher D. Byrne. Human skeletal muscle PPAR expression correlates with fat metabolism gene expression but not BMI or insulin sensitivity. Am J Physiol Endocrinol Metab 286: E168–E175, 2004. First published September 30, 2003; 10.1152/ajpendo.00232.2003.—Peroxisome proliferator-activated receptor(PPAR ) is a key regulator of fatty acid oxi...

Deleterious environmental stimuli cause the airway epithelium to respond with increased secretions of mucus, reaction of oxygen/nitrogen species, changes in ciliary beating, and the influx of inflammatory cells. The epithelium is a target for factors released by infiltrating inflammatory cells, and has recently been shown to serve as an effector of such inflammation. Molecular mechanisms regula...

In this paper we introduce a model of local and global control policies regulating decentralized virtual communities of heterogeneous agents. We illustrate how the model can be formalized if agents attribute mental attitudes to normative systems.

This paper extends the scope of the model of regulation of social exchanges based on the concept of a supervisor of social equilibrium. We allow the supervisor to interact with personality-based agents that control the supervisor access to their internal states, behaving either as transparent agents (agents that allow full external access to their internal states) or as non-transparent agents (...

Current lipid-altering agents that lower low density lipoprotein cholesterol (LDL-C) primarily through increased hepatic LDL receptor activity include statins, bile acid sequestrants/resins and cholesterol absorption inhibitors such as ezetimibe, plant stanols/sterols, polyphenols, as well as nutraceuticals such as oat bran, psyllium and soy proteins; those currently in development include newe...